Glycogen synthase kinase-3 β mediated regulation of matrix metalloproteinase-9 and its involvement in oral squamous cell carcinoma progression and invasion

ConclusionsCollectively, our results show that MMP-9 overexpression and activation are important events occurring during OSCC progression/invasion and that this overexpression/activation is regulated by c-Myc, active MMP-2 and inactive GSK3 β mediated pathways.
Source: Cellular Oncology - Category: Cancer & Oncology Source Type: research