World Antibiotic Awareness Week

Professor Dame Sally Davies, England's Chief Medical Officer, recently warned that the world could face a  " post-antibiotic apocalypse.” She urged that, unless action is taken to halt the practices that have allowed antibiotic resistance to spread and ways are found to develop new types of antibiotics, we could return to the days when simple wounds, infections or routine operations, are life-threatening. To mark   World Antibiotic Awareness Week, 13th-19th November,  we are highlighting Cochrane  evidence which supports decision-making in the appropriate use of antibiotics. Press Release:Shared decision making and antibiotic use for acute respiratory  infections in primary care (read in Spanish).Improving antibiotic prescribing  in hospitalAntibiotics for preventing recurrent sore throatAntibiotics for sore throatTesting blood procalcitonin levels to decide when to start and stop antibiotics in adults with acute respiratory tract infections Biomarkers as point-of-care tests to guide antibiotic use for acute respiratory infections Antibiotics for acute otitis media in children Antibiotics for glue earRapid antigen detection tests (RADTs) for group A streptococcus (GAS) in children with pharyngitisAntibiotics for operative vaginal delivery?Antibiotics for episiotomy repair?Antibiotic prophylaxis for women having cesarean sectionTiming of IV prophylactic antibiotics for women having caesarean deliv...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news

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Publication date: July 2018Source: Revista Portuguesa de Cardiologia (English Edition), Volume 37, Issue 7Author(s): Cristina Cruz, Teresa Pinho, Vânia Ribeiro, Cláudia Camila Dias, José Silva Cardoso, Maria Júlia MacielAbstractIntroduction and AimsIntrinsic aortopathy can lead to dilatation late after tetralogy of Fallot (TOF) repair. Its extent and prevalence are not known. We aimed to assess aortic dimensions and elasticity and to find predictors of aortic dilatation.MethodsA total of 126 adults were prospectively included after TOF repair and compared to 63 gender- and age-matched controls. T...
Source: Revista Portuguesa de Cardiologia - Category: Cardiology Source Type: research
In this study, we analyzed interferon (IFN)- γ-producing cells and M1/M2 macrophage polarization inLegionella pneumophila pneumonia following anti-Gr-1 antibody treatment. Anti-Gr-1 treatment induced an M1-to-M2 shift of macrophage subtypes in the lungs and weakly in the peripheral blood, which was associated with increased mortality in legionella-infected mice. CD8+ T lymphocytes and natural killer cells were the dominant sources of IFN- γ in the acute phase, and anti-Gr-1 treatment reduced the number of IFN-γ-producing CD8+ T lymphocytes. In the CD3-gated population, most Gr-1-positive cells were CD8+ T...
Source: Journal of Innate Immunity - Category: Allergy & Immunology Source Type: research
ConclusionsLncRNA XLOC_009167 could serve as a novel diagnostic biomarker to distinguish lung cancer from benign lung disease and healthy controls.
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
Publication date: Available online 16 December 2017Source: Clinica Chimica ActaAuthor(s): Taiane S. Fonseca, Ângela G. Vasconcellos, Dominique Gendrel, Olli Ruuskanen, Cristiana M. Nascimento-CarvalhoAbstractBackgroundChildhood community-acquired pneumonia is a common and potentially life-threatening illness in developing countries. We assessed the prognostic value of serum procalcitonin level upon admission on clinical response to antibiotic treatment.MethodsOut of 89 patients, the median (IQR) age was 19(12–29) months and 60% were boys. Viral (49.5%), typical bacterial (38%) and atypical bacterial (12.5%) inf...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
Authors: Menéndez R, Amara-Elori I, Méndez R PMID: 30016132 [PubMed - as supplied by publisher]
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
While studying two rare inherited cancer syndromes, Yale Cancer Center (YCC) scientists have found the cancers are driven by a breakdown in how cells repair their DNA.07/18/2018
Source: Kidney Cancer Association - Category: Urology & Nephrology Source Type: news
Conclusion: Performing an ACDF for resection of an intradural calcified/ossified disc with OPLL often results in both a dural defect and CSF fistula. As the arachnoid membrane rarely remains intact, the spine surgeon should be prepared to immediately perform both a WP shunt, and subsequently, an LP. In this case, following an ACDF, resection of an intradural ossified disc with OPLL resulted in an isolated dural defect without a CSF fistula and did not require no dural repair or shunting procedures. PMID: 30009083 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
This journal article concludes that recurrent acute cough with cough-free periods of at least a week between bouts is probably due to viral colds. It presents a practical approach to diagnosis and management of the otherwise apparently healthy child with recurrent lower respiratory tract infections.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
A full year after acquiring Claris Injectables, FDA has hit Baxter with a warning letter in connection with the agency’s inspection of the acquired facilities in Ahmedabad, India. Baxter added Claris to the pharmaceuticals side of its business last year and the $625 million deal is expected to provide a foundational growth platform for the company. FDA began an inspection of the Claris facilities the same day the deal closed, July 27, 2017, which resulted in a Form-483 noting several observations. The company responded to the 483 on Aug. 25 and said in a recent regulatory filing with the Securities and Exchange Commi...
Source: MDDI - Category: Medical Devices Authors: Tags: Regulatory and Compliance Business Source Type: news
Oncostatin M promotes the osteogenic differentiation of mouse MC3T3‑E1osteoblasts through the regulation of monocyte chemotactic protein‑1. Mol Med Rep. 2018 Jul 09;: Authors: Zheng W, Guan J Abstract The present study investigated the function of oncostatin M (OSM), which may be associated with monocyte chemotactic protein‑1 (MCP‑1), on mouse MC3T3‑E1 osteoblast development and bone remodeling. Levels of MCP‑1, macrophage inflammatory protein 1α (MIP1α) and regulated upon activation normal T cell expressed and secreted (RANTES) were measured by ELISA. Cell viability, migration ...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
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