Role of liver magnetic resonance imaging in hyperferritinaemia and the diagnosis of iron overload.

Role of liver magnetic resonance imaging in hyperferritinaemia and the diagnosis of iron overload. Swiss Med Wkly. 2017 Nov 09;147:w14550 Authors: Ruefer A, Bapst C, Benz R, Bremerich J, Cantoni N, Infanti L, Samii K, Schmid M, Vallée JP Abstract Hyperferritinaemia is a frequent clinical problem. Elevated serum ferritin levels can be detected in different genetic and acquired diseases and can occur with or without anaemia. It is therefore important to determine whether hyperferritinaemia is due to iron overload or due to a secondary cause. The main causes of iron overload are intestinal iron hyperabsorption disorders and transfusion-dependent disorders. Iron homeostasis and iron overload are quantified by different diagnostic approaches. The evaluation of serum ferritin and transferrin saturation is the first diagnostic step to identify the cause of hyperferritinaemia. The assessment of liver iron concentration by liver biopsy or magnetic resonance imaging (MRI) may guide the further diagnostic and therapeutic workup. Liver biopsy is invasive and poorly accepted by patients and should only be carried out in selected patients with hereditary haemochromatosis. As a non-invasive approach, MRI is considered the standard method to diagnose and to monitor both hepatic iron overload and the effectiveness of iron chelation therapy in many clinical conditions such as thalassaemia and myelodysplastic syndromes. Accurate evaluation and monitoring of iron ove...
Source: Swiss Medical Weekly - Category: General Medicine Authors: Tags: Swiss Med Wkly Source Type: research

Related Links:

Chem. Commun., 2018, Accepted Manuscript DOI: 10.1039/C8CC08243J, CommunicationAswathy Joseph, Marilyn Mary Xavier, Jacek Fal, Gawe ł Żyła, Soorya Sasi, Pankajakshan Radhakrishnan Nair, A. S. Padmanabhan, Suresh Mathew Iron oxide based-electroactive IoNanofluid with high dielectric constant, high stability and low viscosity was synthesized from ferrous sulphate heptahydrate via a facile microwave assisted one-step route in 1-butyl-4-methylpyridinium chloride. The... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
ESTIMATION OF SHAPE AND GROWTH BRAIN NETWORK ATLASES FOR CONNECTOMIC BRAIN MAPPING IN DEVELOPING INFANTS. Proc IEEE Int Symp Biomed Imaging. 2018 Apr;2018:985-989 Authors: Rekik I, Li G, Lin W, Shen D Abstract In vivo brain connectomics have heavily relied on using functional and diffusion Magnetic Resonance Imaging (MRI) modalities to examine functional and structural relationships between pairs of anatomical regions in the brain. However, research work on brain morphological (i.e., shape-to-shape) connections, which can be derived from T1-w and T2-w MR images, in both typical and atypical development...
Source: Proceedings - International Symposium on Biomedical Imaging - Category: Radiology Tags: Proc IEEE Int Symp Biomed Imaging Source Type: research
Authors: Zhao M, Wang L, Chen J, Nie D, Cong Y, Ahmad S, Ho A, Yuan P, Fung SH, Deng HH, Xia J, Shen D Abstract Automatic segmentation of medical images finds abundant applications in clinical studies. Computed Tomography (CT) imaging plays a critical role in diagnostic and surgical planning of craniomaxillofacial (CMF) surgeries as it shows clear bony structures. However, CT imaging poses radiation risks for the subjects being scanned. Alternatively, Magnetic Resonance Imaging (MRI) is considered to be safe and provides good visualization of the soft tissues, but the bony structures appear invisible from MRI. Ther...
Source: MICCAI International Conference on Medical Image Computing and Computer-Assisted Intervention - Category: Radiology Tags: Med Image Comput Comput Assist Interv Source Type: research
This article outlines the basic science behind the mechanical and inflammatory model of development of PTOA of the ankle. The purpose of this article is to review the state of literature and understanding of ankle PTOA and serve as a foundation for future research aimed at reducing severity and progression of PTOA. Level of Evidence: Diagnostic Level V. See Instructions for Authors for a complete description of levels of evidence.
Source: Techniques in Foot and Ankle Surgery - Category: Orthopaedics Tags: Special Focus: Advances in Ankle Fracture Management Source Type: research
CONCLUSION: Our analysis confirms that SMILE regimen, which is current standard to treat advanced-stage ENKTL may be associated with more severe hematological toxicity compared to other L-asparaginase combinations, including methotrexate-based (AspaMetDex, MESA and MEDA) or gemcitabine-based (GELOX, PGEMOX, DDGP, GDL, GOLD, GLIDE) or CCRT-based regimens. PMID: 30449214 [PubMed - as supplied by publisher]
Source: Expert Review of Anticancer Therapy - Category: Cancer & Oncology Tags: Expert Rev Anticancer Ther Source Type: research
Condition:   Treatment of Iron Defiency Anemia Interventions:   Drug: Lactoferrin;   Drug: ferrous poly maltose Sponsor:   South Valley University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Acute Myeloid Leukemia;   Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome;   Cancer Fatigue;   Secondary Acute Myeloid Leukemia Interventions:   Behavioral: Cognitive Behavior Therapy;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration Sponsors:   M.D. Anderson Cancer Center;   National Cancer Institute (NCI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Patient With Ascending Aortic Aneurysm With Surgical Indication for Replacement Interventions:   Procedure: Cardiac MRI;   Other: in-vitro elasticity tests Sponsor:   Centre Hospitalier Universitaire Dijon Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
STOCKHOLM, Nov 20, 2018 -- (Healthcare Sales &Marketing Network) -- Swedish Orphan Biovitrum AB (publ) (Sobi™) (STO: SOBI), an international biopharmaceutical company dedicated to rare diseases, and Novimmune SA, a Swiss biotech company, today announce t... Biopharmaceuticals, FDA Swedish Orphan Biovitrum, Gamifant, emapalumab, Lymphohistiocytosis
Source: HSMN NewsFeed - Category: Pharmaceuticals Source Type: news
ConclusionIn this review, we summarize pathways and mechanisms of ferroptosis in HCC and other digestive system neoplasms such as gastric cancer, pancreatic cancer and colorectal cancer and point out the trends of ferroptosis in HCC.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
More News: Anemia | General Medicine | Genetics | Haemochromatosis | Iron | Liver | MRI Scan | Myelodysplastic Syndrome | Radiology | Switzerland Health | Urology & Nephrology