Log in to search using one of your social media accounts:


Role of liver magnetic resonance imaging in hyperferritinaemia and the diagnosis of iron overload.

Role of liver magnetic resonance imaging in hyperferritinaemia and the diagnosis of iron overload. Swiss Med Wkly. 2017 Nov 09;147:w14550 Authors: Ruefer A, Bapst C, Benz R, Bremerich J, Cantoni N, Infanti L, Samii K, Schmid M, Vallée JP Abstract Hyperferritinaemia is a frequent clinical problem. Elevated serum ferritin levels can be detected in different genetic and acquired diseases and can occur with or without anaemia. It is therefore important to determine whether hyperferritinaemia is due to iron overload or due to a secondary cause. The main causes of iron overload are intestinal iron hyperabsorption disorders and transfusion-dependent disorders. Iron homeostasis and iron overload are quantified by different diagnostic approaches. The evaluation of serum ferritin and transferrin saturation is the first diagnostic step to identify the cause of hyperferritinaemia. The assessment of liver iron concentration by liver biopsy or magnetic resonance imaging (MRI) may guide the further diagnostic and therapeutic workup. Liver biopsy is invasive and poorly accepted by patients and should only be carried out in selected patients with hereditary haemochromatosis. As a non-invasive approach, MRI is considered the standard method to diagnose and to monitor both hepatic iron overload and the effectiveness of iron chelation therapy in many clinical conditions such as thalassaemia and myelodysplastic syndromes. Accurate evaluation and monitoring of iron ove...
Source: Swiss Medical Weekly - Category: General Medicine Authors: Tags: Swiss Med Wkly Source Type: research

Related Links:

Blood transfusions are variable across centers in the Vascular Quality Initiative (VQI). Transfusions are associated with a higher postoperative myocardial infarction and death risk after open abdominal aortic aneurysm repair and lower extremity arterial bypass grafting. Efforts to reduce transfusion may focus on center variability, gender, and preoperative anemia.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Vascular vantage point Source Type: research
Zahari N. Tchopev, Ping-Hong Yeh, Greg W. Morgan, Eric Meyer, Johanna M. Wolf, John M. Ollinger, Gerard P. Riedy, Lisa C. Young
Source: Frontiers in Neurology - Category: Neurology Source Type: research
A national campaign has set aggressive targets for the reduction of stunting and anaemia
Source: FT.com - Drugs and Healthcare - Category: Pharmaceuticals Source Type: news
AbstractAn autopsy involves examination of a body using invasive methods such as dissection, and includes various tests using samples procured during dissection. During medicolegal autopsies, the blood carboxyhemoglobin concentration is commonly measured using the AVOXimeter ® 4000 as a point-of-care test. When evaluating the body following hypovolemic shock, characteristics such as reduced livor mortis or an anemic appearance of the viscera can be identified, but these observations arequite subjective. Thus, a more objective test is required for the postmortem diagnos is of anemia. In the present study, the AVOXimeter...
Source: Forensic Science, Medicine, and Pathology - Category: Forensic Medicine Source Type: research
AbstractPurpose of ReviewPheochromocytomas and paragangliomas (PPGLs) are uncommon catecholamine-producing neuroendocrine neoplasms that usually present with secondary hypertension. This review is to update the current knowledge about these neoplasms, the pathophysiology, genetic aspects and diagnostic and therapeutic algorithms based on scientific literature mostly within the past 3  years.Recent FindingsEighty to eighty-five percent of PPGLs arise from the adrenal medulla (pheochromocytomas; PCCs) and the remainder from the autonomic neural ganglia (paragangliomas; PGLs). Catecholamine excess causes chronic or parox...
Source: Current Hypertension Reports - Category: Primary Care Source Type: research
In this study, to discover the effects of iron and vitamin B12 deficiencies on the hematopoietic stem cells, we studied CFU assay from peripheral blood. One hundred and two children were included in our study and were evaluated in five categories: iron deficiency, iron deficiency anemia, vitamin B12 deficiency, iron and vitamin B12 deficiency, and controls. As a result of statistical analysis, no significant difference was detected between five groups in terms of CFU assays. The results of our study suggest that, in emergent situations, stem cell samples can be collected before treatment with B12 or iron which are common d...
Source: Pediatric Transplantation - Category: Transplant Surgery Authors: Tags: ORIGINAL ARTICLE Source Type: research
ConclusionWe report a case treated with endoscopic procedure without open surgery for acute pyogenic spondylodiscitis following vertebroplasty.
Source: European Spine Journal - Category: Orthopaedics Source Type: research
The superior temporal sulcus (STS) is an anatomical structure that increasingly interests researchers. This structure appears to receive multisensory input and is involved in several perceptual and cognitive core functions, such as speech perception, audiovisual integration, (biological) motion processing and theory of mind capacities. In addition, the superior temporal sulcus is not only one of the longest sulci of the brain, but it also shows marked functional and structural asymmetries, some of which have only been found in humans. To explore the functional‐structural relationships of these asymmetries in more detail,...
Source: Scandinavian Journal of Psychology - Category: Psychiatry & Psychology Authors: Tags: Original Article Source Type: research
Abstract Assessing language development in the first postnatal year is difficult, as receptive and expressive skills are rudimentary. Although outward manifestations of change are limited, the auditory language system is thought to undergo critical development at this age, as the foundations are laid for the rapid onset of spoken language in the second and third years. We recruited 11 infants, 7 healthy controls (gestational age = 40.69 ± 0.56; range from 40 to 41.43) and preterm babies (gestational age = 28.04 ± 0.95; range from 27.43 to 29.43) who unde...
Source: Developmental Psychobiology - Category: Psychiatry & Psychology Authors: Tags: RESEARCH ARTICLE Source Type: research
ConclusionThe BHA had excellent combined sensitivity and specificity to detect dementia and MCI, including MCI due to diverse etiologies. The subtests provide efficient, valid measures of neurocognition that are critical in making a differential diagnosis.
Source: Journal of the American Geriatrics Society - Category: Geriatrics Authors: Tags: Brief Methodological Reports Source Type: research
More News: Anemia | General Medicine | Genetics | Haemochromatosis | Iron | Liver | MRI Scan | Myelodysplastic Syndrome | Radiology | Switzerland Health | Urology & Nephrology