" The role of CXCR3 in neurological diseases".

" The role of CXCR3 in neurological diseases". Curr Neuropharmacol. 2017 Nov 09;: Authors: Zhou YQ, Liu DQ, Chen SP, Sun J, Zhou XR, Xing C, Ye DW, Tian YK Abstract Neurological diseases have become an obvious challenge due to insufficient therapeutic intervention. Therefore, novel drugs for various neurological disorders are in desperate need. Recently, compelling evidence has demonstrated that chemokine receptor CXCR3, which is a G protein-coupled receptor in the CXC chemokine receptor family, may play a pivotal role in the development of neurological diseases. The expression level of CXCR3 in T cells was significantly elevated in several neurological diseases, suggesting a potential therapeutic role of CXCR3 antagonists. In this review, we summarize the recent advances suggesting the involvement of CXCR3 in the pathogenesis of neurological diseases, including multiple sclerosis, glioma, Alzheimer's disease, chronic pain, human T-lymphotropic virus type 1-associated myelopathy and bipolar disorder. The aim of this review is to provide evidence for the potential of CXCR3 as a therapeutic target for neurological diseases. PMID: 29119926 [PubMed - as supplied by publisher]
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Neuropharmacol Source Type: research