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See something of interest? Please share our postings with colleagues in your institutions! Spotlight Funding available! The National Network of Libraries of Medicine, Middle Atlantic Region, is accepting applications for health information outreach, health literacy initiatives, emergency preparedness partnerships and health sciences library projects. Applications will be due by COB on December 1. See a recent blog post from Executive Director, Kate Flewelling for details, or review our funding opportunities and start your application today! Rural Health Week begins on Monday, November 13! Wondering how you can participate? The Health Resources and Services Administration (HRSA) is offering a number of online events next week, including Twitter chats and webcasts. Join the conversation by using #OurRural on social media. Details. The National Library of Medicine is making some changes to Interlibrary Loan Services (ILL) beginning in January 2018. Details. National Network of Libraries of Medicine News New Resources for the Opioid Crisis – MARquee News Highlights Reflections on: Big Data in Healthcare: Exploring Emerging Roles – SEA Currents Beyond Anecdotes: Story Collection Methods for Program Evaluation – NEO Shop Talk HyperDocs for Libraries – NTO News The Fall 2017 offering for the Health Sciences Library Association of New Jersey (HSLANJ) Group Licensing Initiative (GLI) is now available. NNLM MAR members are eligible to participate! The deadl...
Source: NN/LM Middle Atlantic Region Blog - Category: Databases & Libraries Authors: Tags: Weekly Postings Source Type: news

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CONCLUSIONS: The use of echocardiographic criteria for the presence of PH is adequate for the screening of COPD patients. Patients with acute exacerbation of COPD and possible/likely PH demonstrate worse mortality compared to patients unlikely to have PH. PMID: 29471029 [PubMed - as supplied by publisher]
Source: Hellenic Journal of Cardiology - Category: Cardiology Tags: Hellenic J Cardiol Source Type: research
Authors: Bai M, Liu Y, Zhou F, Zhang Y, Zhu Q, Zhang L, Zhang Q, Wang S, Zhu K, Wang X, Zhou L Abstract Glucose promotes insulin secretion primarily via its metabolism and the production of metabolic coupling factors in beta-cells. The activation of AMP-activated protein kinase (AMPK), an energy sensor, results in a decrease in insulin secretion from beta-cells, but its mechanism remains largely unknown. Berberine, an oral anti-diabetic drug, has been shown to activate AMPK in multiple peripheral tissues. Here, we examined the effects of berberine and AMPK activation on insulin secretion and glucose oxidation in ra...
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
ConclusionsThese data highlighted vitamin D pathway gene SNPs and HCC relationship in the Italian population; further studies are required.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
This article considers evidence for the efficacy and safety of bronchial thermoplasty from clinical trials and observational studies in clinical practice. Its place in the management of severe asthma, predictors of response and mechanisms of action are reviewed. Expert commentary: Bronchial thermoplasty improves quality of life and reduces exacerbations in moderate to severe asthma. Morbidity from asthma is increased during treatment. Overall, patients treated in clinical practice have worse baseline characteristics and comparable clinical outcomes to trial data. Follow-up studies provide reassurance on long-term safety. D...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
Authors: Fragoso CAV, Gill TM, Leo-Summers LS, Van Ness PH Abstract Clinical trials of pharmacotherapy in chronic obstructive pulmonary disease (COPD) often include older persons with moderate-to-severe airflow-obstruction, as defined by the Global Initiative for chronic Obstructive Lung Disease (GOLD). In this context, spirometric airflow-obstruction establishes COPD. Because GOLD misidentifies COPD and its severity in older persons, we set out to apply more age-appropriate spirometric criteria from the Global Lung function Initiative (GLI) in a prior clinical trial of COPD pharmacotherapy, specifically the Toward...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - Category: Respiratory Medicine Tags: COPD Source Type: research
Authors: Gulart AA, Munari AB, Klein SR, Santos da Silveira L, Mayer AF Abstract The study objective was to determine a cut-off point for the Glittre activities of daily living (ADL)test (TGlittre) to discriminate patients with normal and abnormal functional capacity. Fifty-nine patients with moderate to very severe COPD (45 males; 65 ± 8.84 years; BMI: 26 ± 4.78 kg/m2; FEV1: 35.3 ± 13.4% pred) were evaluated for spirometry, TGlittre, 6-minute walk test (6 MWT), physical ADL, modified Medical Research Council scale (mMRC), BODE index, Saint George's Respiratory Questionnaire (SGRQ), a...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - Category: Respiratory Medicine Tags: COPD Source Type: research
Authors: Perciaccante A, Charlier P, Negri C, Coralli A, Appenzeller O, Bianucci R Abstract A1AT deficiency- a genetically inherited autosomal codominant disease with more than 120 identified alleles- was first identified by Laurell and Eriksson in 1963. The most common hereditary disorder in adults, A1AT causes an increased risk of developing pulmonary emphysema and liver disease. In A1AT patients, lung disease generally presents at a younger age than "usual" chronic obstructive pulmonary disease (COPD) and it may be misdiagnosed as asthma. Because A1AT deficiency patients can show the same clinical feat...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - Category: Respiratory Medicine Tags: COPD Source Type: research
This study presents a rational design approach to discovery synthetic peptide vaccine candidates from endogenous proteins for chronic non-infectious diseases immunological therapeutics. The approach described the screening of key antigenic amino acid residues of the interleukine-13, which is up-regulated expression in asthma, followed by the development of immunological helper epitope peptides via an integrative computational and experimental method. Notably, this totally synthetic peptide vaccine was capable of stimulating humoral immune responses much stronger than those of parental antigenic peptides by enhancing the ef...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
The Turmeric Forskolin: the main objective of this diet is to control the body's insulin production by limiting what it eats. It does this by limiting the intake of carbohydrates and increasing protein intake. The drop in carbohydrate intake leads to weight loss in many people.
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Source Type: forums
CONCLUSIONS: This first report on ARL15 expression in RASF and its likely role in inflammation and metabolic syndromes through a TNF independent pathway, encourages hypothesis-free studies to identify additional pathways underlying RA disease biology. PMID: 29465355 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
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