See something of interest? Please share our postings with colleagues in your institutions! Spotlight Funding available! The National Network of Libraries of Medicine, Middle Atlantic Region, is accepting applications for health information outreach, health literacy initiatives, emergency preparedness partnerships and health sciences library projects. Applications will be due by COB on December 1. See a recent blog post from Executive Director, Kate Flewelling for details, or review our funding opportunities and start your application today! Rural Health Week begins on Monday, November 13! Wondering how you can participate? The Health Resources and Services Administration (HRSA) is offering a number of online events next week, including Twitter chats and webcasts. Join the conversation by using #OurRural on social media. Details. The National Library of Medicine is making some changes to Interlibrary Loan Services (ILL) beginning in January 2018. Details. National Network of Libraries of Medicine News New Resources for the Opioid Crisis – MARquee News Highlights Reflections on: Big Data in Healthcare: Exploring Emerging Roles – SEA Currents Beyond Anecdotes: Story Collection Methods for Program Evaluation – NEO Shop Talk HyperDocs for Libraries – NTO News The Fall 2017 offering for the Health Sciences Library Association of New Jersey (HSLANJ) Group Licensing Initiative (GLI) is now available. NNLM MAR members are eligible to participate! The deadl...
Breast cancer is the leading diagnosed cancer for women globally. Evolution of breast cancer in tumorigenesis, metastasis and treatment resistance appears to be driven by the aberrant gene expression and protein degradation encoded by the cancer genomes. The uncontrolled cancer growth relies on these cellular events, thus constituting the cancerous programs and rendering the addiction towards them. These programs are likely the potential anticancer biomarkers for Personalized Medicine of breast cancer. This review intends to delineate the impact of the CRSPR/Cas-mediated genome editing in identification and validation of t...
In conclusion, we suggest that, castrate-resistant prostate cancers progression might be retarded with the combination of MYC and chemical JNK inhibitors, involving AR-dependent mechanism.
Conclusions: The cells rely more on glucose/gltamine have a stronger sensitivity to glucose/glutamine depletion or glycolysis/ glutaminolysis inhibition and a lessened sensitivity to glutaminolysis/glycolysis inhibitors. To target tumor metabolism based on metabolic characteristics may provide a new therapeutic strategy for the treatment of B cell lymphoma.
NHS boss Simon Stevens noted that young people come to think of smoking marijuana as safe in countries where it has been decriminalised.
Treatment of advanced heart failure with implantable LVADs is increasing, driven by profound unmet patient need despite potential serious complications: bleeding, infection, and thrombus. The experimental objective was to develop a sensitive imaging approach to assess early thrombus accumulation in LVADs under operational high flow and high shear rates.Methods: A monomeric bifunctional ligand with a fibrin-specific peptide, a short spacer, and 99mTc chelating amino acid sequence (F1A) was developed and compared to its tetrameric PEG analogue (F4A).Results: 99mTc attenuation by LVAD titanium (1 mm) was 23%. 99mTc-F1A affini...
Conclusions: These results identify a novel crosstalk signaling pathway between adipose tissue and skeletal muscle in the development of insulin resistance, and indicate that adipose tissue-derived miR-27a may play a key role in the development of obesity-triggered insulin resistance in skeletal muscle.
Conclusions: IRS4, as a new substrate of CHIP, is negatively regulated by CK1γ2 at the posttranslational level, and specific CK1γ2 agonists may be a potentially effective strategy for treating patients with osteosarcoma.
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