Hemoglobin-Dilution Method: Effect of Measurement Errors on Vascular Volume Estimation.

This study uses a "Monte Carlo" approach to determine the distribution of these errors. The finding was that these errors could be closely approximated with a log-normal distribution that can be parameterized by a geometric mean (X) and a dispersion factor (S). When the ratio of successive Hb concentrations is used to estimate blood volume, normally distributed hemoglobin measurement errors tend to produce exponentially higher values of X and S as the SD of the measurement error increases. The longer tail of the distribution to the right could produce much greater overestimations than would be expected from the SD values of the measurement error; however, it was found that averaging duplicate and triplicate hemoglobin measurements on a blood sample greatly improved the accuracy.
PMID: 29118825 [PubMed - in process]

Source: Computational and Mathematical Methods in Medicine - November 10, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research