Re-administration of Intravenous Alteplase in Acute Ischemic Stroke Patients: Case Series and Systematic Review

Background: Due to a high risk of recurrence of ischemic events, some patients may be candidates for re-administration of intravenous (IV) alteplase. Methods: We performed a single center review and performed a search on PubMed from January 1966 to April 2014 for cases of re-administration of alteplase. Favorable outcome was defined by a modified Rankin scale of 0-2 at discharge or at 1-3 months, improvement of ≥4 points within 24 hours in the National Institutes of Health Stroke Scale (NIHSS) score, or as a major improvement in the 72-hour NIHSS score.
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research

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CONCLUSION: This study describes the current status of acute stroke care in Korea. Despite quite acceptable quality of stroke care, it suggests regional and hospital disparities. Expansion of stroke units, stroke center certification or accreditation, and connections between stroke centers and emergency medical services are highly recommended. PMID: 32449325 [PubMed - in process]
Source: Journal of Korean Medical Science - Category: Biomedical Science Tags: J Korean Med Sci Source Type: research
AbstractThe usefulness of brain imaging studies in dizzy patients presenting to the emergency department (ED) is controversial. We aimed to assess the ‘real-world’ probability of ischemic stroke and other acute brain lesions (ABLs) in these patients to create an algorithm that helps decision-making on whether which and when brain imaging is needed. By reviewing medical records, we identified 610 patients presenting with dizziness, vertigo or i mbalance to our university hospital’s ED and receiving neurological workup. We collected timing/triggers of symptoms, ABCD2 score, focal neurological abnormalities,...
Source: Journal of Neurology - Category: Neurology Source Type: research
Source: Indian Journal of Clinical Biochemistry - Category: Biochemistry Source Type: research
It is critical that Randomized Controlled Trials(RCTs) present complete and transparent reporting. The present study aims to determine the reporting quality of double-blind RCTs for medicinal interventions in patients with ischemic stroke, based on the 2010 CONSORT-statement.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Source Type: research
This study aimed to examine the effect of low DBP (
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Condition:   Ischemic Stroke Interventions:   Procedure: Remote ischemic conditioning;   Other: standard medical therapy Sponsors:   San Gerardo Hospital;   University of Milano Bicocca;   Università degli Studi dell'Aquila;   University of Roma La Sapienza;   Istituto Di Ricerche Farmacologiche Mario Negri;   Ministero della Salute, Italy Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 25 May 2020Source: Journal of Advanced ResearchAuthor(s): Guilong Zhang, Zhihan Zhu, Hong Wang, Yongbo Yu, Wanghao Chen, Ahmed Waqas, Yezhong Wang, Lukui Chen
Source: Journal of Advanced Research - Category: Research Source Type: research
Authors: Gattellari M, Goumas C, Jalaludin B, Worthington JM Abstract OBJECTIVES: Epidemiological trends for major causes of death and disability, such as stroke, may be monitored using administrative data to guide public health initiatives and service delivery. METHODS: We calculated admissions rates for ischaemic stroke, intracerebral haemorrhage and subarachnoid haemorrhage between 1 January 2005 and December 31st, 2013 and rates of 30-day mortality and 365-day mortality in 30-day survivors to 31 December 2014 for patients aged 15 years or older from New South Wales, Australia. Annual Average Percentage...
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03805
Source: Journal of the American Chemical Society - Category: Chemistry Authors: Source Type: research
This cohort study examines the age-specific prevalence and prognosis of asymptomatic intracranial stenosis in British patients with transient ischemic attack and minor stroke.
Source: JAMA Neurology - Category: Neurology Source Type: research
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