A randomized placebo-controlled trial of progesterone with or without hypothermia in patients with acute severe traumatic brain injury

Conclusions: A strong evidence for prophylactic hypothermia and a weak evidence for progesterone therapy was observed for a better primary outcome at 6 months as compared to the placebo. A similar trend was observed at a 1-year follow-up. Contrary to our hypothesis, prophylactic hypothermia therapy suppressed the beneficial effects of progesterone therapy in sTBI patients. The complex cascades of factors responsible for such interactions are still unknown and need to be further determined.
Source: Neurology India - Category: Neurology Authors: Source Type: research