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Cardiomyopathy in acromegaly and the effect of trans-sphenoidal surgery

Subhash Yadav, Eesh BhatiaNeurology India 2017 65(6):1223-1224
Source: Neurology India - Category: Neurology Authors: Source Type: research

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Conclusion: Reduction in growth hormone levels and insulin-like growth factor type 1 can decrease the LVM and LVMI, which directly or indirectly contributes to the improvement in diastolic as well as systolic function and probably mortality.
Source: Neurology India - Category: Neurology Authors: Source Type: research
Abstract In patients with acromegaly, chronic excess of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) leads to the development of acromegalic cardiomyopathy. Its main features are biventricular hypertrophy, diastolic dysfunction, and in later stages, systolic dysfunction and congestive heart failure. Surgical and/or pharmacological treatment of acromegaly and control of cardiovascular risk factors help reverse some of these pathophysiologic changes and decrease the high risk of cardiovascular complications. PMID: 28740584 [PubMed - in process]
Source: Methodist DeBakey Cardiovascular Journal - Category: Cardiology Authors: Tags: Methodist Debakey Cardiovasc J Source Type: research
AbstractAcromegaly is associated with an enhanced mortality, with cardiovascular and respiratory complications representing not only the most frequent comorbidities but also two of the main causes of deaths, whereas a minor role is played by metabolic complications, and particularly diabetes mellitus. The most prevalent cardiovascular complications of acromegaly include a cardiomyopathy, characterized by  cardiac hypertrophy and diastolic and systolic dysfunction together with arterial hypertension, cardiac rhythm disorders and valve diseases, as well as vascular endothelial dysfunction. Biochemica...
Source: Pituitary - Category: Endocrinology Source Type: research
We reported a case of a 48 years old man with acromegalic cardiomyopathy caused by pituitary adenoma. Despite the successful transsphenoidal resection of the tumour, the patient was re-hospitalized for ventricular arrhythmic storms that led to cardiogenic shock which required mechanical hemodynamic support with intra aortic balloon pump, venoarterial extracorporeal membrane oxygenation and urgent heart transplantation.
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Exp Clin Endocrinol Diabetes DOI: 10.1055/s-0042-123710Blockade of the angiotensin-renin system, with angiotensin converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs), has been shown to improve cardiac outcomes following myocardial infarction and delay progression of heart failure. Acromegaly is associated with a disease-specific cardiomyopathy, the pathogenesis of which is poorly understood.The cardiac indices of patients with active acromegaly with no hypertension (Group A, n=4), established hypertension not taking ACEi/ARBs (Group B, n=4) and established hypertension taking ACEi/ARBs (Group C, n=...
Source: Experimental and Clinical Endocrinology and Diabetes - Category: Endocrinology Authors: Tags: Article Source Type: research
AbstractComorbidities related to the cardiovascular system are one of the most prevalent in patients with acromegaly, and contribute to an increased risk of morbidity and all-cause mortality. Specifically, hypertension, cardiomyopathy, heart valve disease, arrhythmias, atherosclerosis, coronary artery disease, and cardiac dysfunction may be frequent findings. Although the underlying physiopathology for each comorbidity may not be fully elucidated, uncontrolled growth hormone/insulin-like growth factor 1 excess, age, prolonged disease duration, and coexistence of other cardio-vascular risk factors are significant influencin...
Source: Endocrine - Category: Endocrinology Source Type: research
In this report, we describe the case of a 73-year-old woman with acromegaly due to a pituitary adenoma diagnosed and treated surgically at the age of 38 but with recurrence and reoperation at the age of 50. She was referred to our cardiology department due to a three-month history of progressively worsening exercise-induced dyspnea and orthopnea under optimal medical therapy. Echocardiography and magnetic resonance imaging revealed severe basal hypertrophy of the interventricular septum (19 mm), dynamic left ventricular outflow tract obstruction with a gradient of 70 mmHg at rest and 120 mmHg with Valsalva maneuver, and sy...
Source: Revista Portuguesa de Cardiologia - Category: Cardiology Source Type: research
Abstract Diabetes mellitus is a frequent complication of acromegaly, a disease characterized by chronic hypersecretion of growth hormone (GH) by a pituitary adenoma. Diabetes occurs commonly but not only as a consequence of an insulin-resistant state induced by GH excess. The development of diabetes in patients with acromegaly is clinically relevant, since such a complication is thought to increase the already elevated cardiovascular morbidity and mortality risk of the disease. Emerging data suggest that a specific cardiomyopathy can be identified in acromegaly patients with diabetes. Moreover, the presence of dia...
Source: Trends in Endocrinology and Metabolism: TEM - Category: Endocrinology Authors: Tags: Trends Endocrinol Metab Source Type: research
Publication date: Available online 24 May 2016 Source:Trends in Endocrinology & Metabolism Author(s): Stefano Frara, Filippo Maffezzoni, Gherardo Mazziotti, Andrea Giustina Diabetes mellitus is a frequent complication of acromegaly, a disease characterized by chronic hypersecretion of growth hormone (GH) by a pituitary adenoma. Diabetes occurs commonly but not only as a consequence of an insulin-resistant state induced by GH excess. The development of diabetes in patients with acromegaly is clinically relevant, since such a complication is thought to increase the already elevated cardiovascular morbidity and mort...
Source: Trends in Endocrinology and Metabolism - Category: Endocrinology Source Type: research
A 61-year-old woman was admitted to our hospital with enlargement of the tongue and progressive fatigue. Electrocardiography showed sinus tachycardia, low QRS voltage in the limb leads and a second-degree atrioventricular block. Echocardiography showed concentric hypertrophic myocardium with restrictive left ventricular (LV) filling (Panel A–B) (Fig. 1). The LV ejection fraction was 49%. Cardiac magnetic resonance (CMR) findings demonstrated bi-atrial enlargement and concentric LV hypertrophy (Panel C, green line).
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Correspondence Source Type: research
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