Emergency blood transfusion practices among anaemic children presenting to an urban emergency department of a tertiary hospital in Tanzania

AbstractBackgroundSevere anaemia contributes significantly to mortality, especially in children under 5  years of age. Timely blood transfusion is known to improve outcomes. We investigated the magnitude of anaemia and emergency blood transfusion practices amongst children under 5 years presenting to the Emergency Department (ED) of Muhimbili National Hospital (MNH) in Tanzania.MethodsThis prospective observational study enrolled children under 5  years old with anaemia, over a 7-week period in August and September of 2015. Anaemia was defined as haemoglobin of
Source: BMC Hematology - Category: Hematology Source Type: research

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Authors: Mallepally AR, Mahajan R, Rustagi T, Goel SA, Das K, Chhabra HS Abstract Study Design: Nonrandomized, prospective, and case-controlled study. Purpose: To evaluate the efficacy and cost-effectiveness of topically applied tranexamic acid (TXA) during different phases of spine surgery. Overview of Literature: Perioperative blood loss is the leading cause of postoperative anemia associated with prolonged stays in hospital and long recovery times. The direct and indirect costs involved pose a significant economic challenge in developing countries. There is no consensus for topical use of tranexamic acid...
Source: Asian Spine Journal - Category: Orthopaedics Tags: Asian Spine J Source Type: research
Publication date: Available online 26 March 2020Source: The Annals of Thoracic SurgeryAuthor(s): Hari Padmanabhan, Matthew J. Brookes, Heyman Luckraz
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
CONCLUSIONS: Earlier GA at diagnosis was associated with an increased risk of aneuploidy and worse pregnancy outcomes, including higher risk of perinatal loss. Fetal therapy was significantly associated with lower perinatal mortality. This article is protected by copyright. All rights reserved. PMID: 32196790 [PubMed - as supplied by publisher]
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Tags: Ultrasound Obstet Gynecol Source Type: research
Since the introduction of recombinant human erythropoietin in the 1980s, the anemia of chronic kidney disease (CKD) can be effectively treated with erythropoiesis-stimulating agents (ESAs) and oral or intravenous iron supplementation. The majority of patients with CKD respond to such treatment; however, some patients do not respond adequately to recommended ESA or iron doses, with higher doses exposing them to an increased risk of adverse effects.1 Although on one hand complete correction of anemia paradoxically worsens patient outcomes, undertreatment of anemia is also associated with reduced quality of life, increased ho...
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrology Digest Source Type: research
Winter is not a boom time for blood donation centers in the U.S. Bad weather, plus circulating flu strains, tend to deter people from giving blood. And the ongoing outbreak of the new coronavirus in the U.S. has worsened an already lean time. According to the American Red Cross, about 1,500 of their blood drives across the country have been canceled because of concerns about the coronavirus. The organization estimates that they’ve lost out on roughly 46,000 donations as a result. Meanwhile, the demand for blood is still strong. “We’ve not seen anything like this at the Red Cross,” says Chris Hrouda,...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Source Type: news
Clozapine-induced anemia: A case-report
. Int J Clin Pharmacol Ther. 2020 Mar 08;: Authors: Eleftheriou G, Butera R, Barcella L, Falanga A Abstract Clozapine, an atypical antipsychotic, can cause potentially life-threating side effects such as agranulocytosis. Our case presents a picture of severe anemia without any depression of the white cells or platelet lines. A 36-year-old man with treatment-resistant schizophrenia was admitted to the Psychiatric Unit for therapy assessment. After admission, he was gradually switched to clozapine treatment, 400 mg/d. General laboratory test results were nor...
Source: International Journal of Clinical Pharmacology and Therapeutics - Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research
AbstractSickle Cell Anemia (SCA) is one of the most common monogenic disorders worldwide. Molecular modifiers of clinical symptoms play an essential role in the amelioration of the effects of the disease. Single Nucleotide Polymorphisms (SNPs) of the BCL11A gene and within the HBS1L-MYB intergenic region, which are located outside the β-globin locus on chromosome 11, are considered to be genetic modifiers that are associated with elevated levels of foetal haemoglobin HbF, and thus they reduce the clinical impact of sickle haemoglobin, HbS. The work reported here aimed to detect the most common SNPs of BCL11A and HBS1L...
Source: Indian Journal of Hematology and Blood Transfusion - Category: Hematology Source Type: research
This study was conducted on 68 β-thalassemia major patients with and without alloantibodies in comparison with 20 healthy individuals with matched age and sex as control group. Enzyme-linked immunosorbent assay (ELISA), flow cytometry, and real-time PCR were performed in order to evaluate serum ferritin and folate levels, frequency of Tregs, and the expression ofFoxP3 andGDF-15 genes, respectively. The percentage and absolute count of Tregs were increased in patients compared with controls (P = 0.0003), but there was no difference between responders and non-responders (P >  0.05). The Tr...
Source: Annals of Hematology - Category: Hematology Source Type: research
We read with great interest the recent article entitled “Impact of Preoperative Iron Deficiency on Blood Transfusion in Elective Cardiac Surgery” published in the Journal of Cardiothoracic and Vascular Anesthesia.1 This prospective observational study aims at assessing the incidence of preoperative iron deficiency (ID) and ID anemia in patients under going elective cardiac surgery. As commonly accepted, ID was defined in this study by a serum ferritin level
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Letter to the Editor Source Type: research
DiscussionThe scale of this trial brings considerable challenges and potential barriers to delivery. Anticipated challenges relate to recruiting and sustaining up to 40 organisations, each with its own culture and context. This complex project with multiple stakeholders across a large geographical area will be managed by experienced senior-level project leaders with a proven track record in advanced project management. The team should ensure effective project governance and communications.Trial registrationISRCTN,ISRCTN11085475. Prospectively registered on 15 February 2018.
Source: Trials - Category: Research Source Type: clinical trials
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