Clinical and molecular characterisation of hereditary and sporadic metastatic colorectal cancers harbouring microsatellite instability/DNA mismatch repair deficiency

Patients treated with chemotherapy for microsatellite unstable (MSI) and/or mismatch repair deficient (dMMR) cancer metastatic colorectal cancer (mCRC) exhibit poor prognosis. We aimed to evaluate the relevance of distinguishing sporadic from Lynch syndrome (LS)-like mCRCs.

Source: European Journal of Cancer - October 19, 2017 Category: Cancer & Oncology Authors: R. Cohen, O. Buhard, P. Cervera, E. Hain, S. Dumont, A. Bardier, J.-B. Bachet, J.-M. Gornet, D. Lopez-Trabada, S. Dumont, R. Kaci, P. Bertheau, F. Renaud, F. Bibeau, Y. Parc, D. Vernerey, A. Duval, M. Svrcek, Thierry Andr é Tags: Original Research Source Type: research