Stress-Induced Hippocampal Volume Loss Is Adult Neurogenesis Independent

Depression is one of the leading cause of disability worldwide and is a major contributor to the overall global burden of disease. Understandably, a considerable amount of research has focused on identifying relevant biomarkers of the disorder. Early studies using magnetic resonance imaging showed reduced hippocampal volumes in patients with major depression (1). These findings have been corroborated by multiple reports, and meta-analyses confirm that depression-associated hippocampal volume loss of up to about 10% is a significant phenomenon.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Early Career Investigator Commentary Source Type: research