In vitro effects of benzimidazole/thioether-copper complexes with antitumor activity on human erythrocytes.

In vitro effects of benzimidazole/thioether-copper complexes with antitumor activity on human erythrocytes. J Inorg Biochem. 2017 Nov 06;178:87-93 Authors: Suwalsky M, Castillo I, Sánchez-Eguía BN, Gallardo MJ, Dukes N, Santiago-Osorio E, Aguiñiga I, Rivera-Martínez AR Abstract Two cytotoxic copper(II) complexes with N-H and N-methylated benzimidazole-derived ligands (Cu-L(1) and Cu-L(1Me); L(1)=bis(2-methylbenzimidazolyl)(2-methylthioethyl)amine, L(1Me)=bis(1-methyl-2-methylbenzimidazolyl)(2-methylthioethyl)amine) were synthesized and exposed to human erythrocytes and molecular models of its membrane. The latter were bilayers built-up of dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylethanolamine (DMPE), classes of lipids present in the external and internal moieties of the human red cell membrane, respectively. Scanning electron microscopy (SEM) of erythrocytes incubated with solutions of both Cu(II) complexes showed that they induced morphological changes to the normal cells to echinocytes, and hemolysis at higher concentrations. Real-time observation of the dose-dependent effects of the complexes on live erythrocytes by defocusing microscopy (DM) confirmed SEM results. The formation of echinocytes implied that complex molecules inserted into the outer moiety of the red cell membrane. X-ray diffraction studies on DMPC and DMPE showed that none of these complexes interacted with DMPE and only Cu-L(1) intera...
Source: Journal of Inorganic Biochemistry - Category: Biochemistry Authors: Tags: J Inorg Biochem Source Type: research

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Publication date: Available online 24 May 2020Source: Materials Science and Engineering: AAuthor(s): Y.C. Wang, L.M. Lei, L. Shi, H.Y. Wan, F. Liang, G.P. Zhang
Source: Materials Science and Engineering: A - Category: Materials Science Source Type: research
ConclusionPurr is a low-level Rust library for working with SMILES. It currently includes a parser that, while not complete, would not take much effort or knowledge of Rust to finish. A SMILES writer should be straightforward to implement given a depth-first traversal and existing Purr data structures. The combination of a low-levelMolecule implementation as already described, and a Purr reader/writer would create a solid foundation for a future cheminformatics toolkit in Rust.
Source: Depth-First - Category: Chemistry Authors: Source Type: blogs
Conclusions: Overall, these observations suggest that activation in the precuneus may reflect extraneous cognitive load driven by upward OF along the pillar and could distract visual attention. The findings of this study highlight the value of a cognitive neuroscientific approach to research and development in the motor vehicle manufacturing industry.
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
AbstractThe transvalvular pressure gradient (TPG) is commonly estimated using the Bernoulli equation. However, the method is known to be inaccurate. Therefore, an adjusted Bernoulli model for accurate TPG assessment was developed and evaluated. Numerical simulations were used to calculate TPGCFD in patient-specific geometries of aortic stenosis as ground truth. Geometries, aortic valve areas (AVA), and flow rates were derived from computed tomography scans. Simulations were divided in a training data set (135 cases) and a test data set (36 cases). The training data was used to fit an adjusted Bernoulli model as a function ...
Source: Medical and Biological Engineering and Computing - Category: Biomedical Engineering Source Type: research
ConclusionThe proposed multiparametric MRI-based SLICs+MTh method performs noninvasive assessment of NACT response in osteosarcoma that may improve cancer treatment monitoring, planning, and overall prognosis.Key Points• The simple linear iterative clustering supervoxels and Otsu multithresholding-based technique (SLICs+MTh) successfully estimates the proportion of necrosis, viable tumor, and edema in osteosarcoma in the course of chemotherapy.• The proposed technique is noninvasive and uses multiparametric MRI to measure necrosis as an indication of anticancer treatment response.• SLICs+MTh-based necrosis w...
Source: European Radiology - Category: Radiology Source Type: research
ConclusionsThe e-ASPECTS software generates robust values for e-ASPECTS and acute infarct volumes when using ST ≤ 4 mm with ST = 1 mm yielding the best performance for predicting baseline stroke severity and clinical outcome after 90 days.Key Points•Clinical utility of automatically derived ASPECTS from computed tomography scans was shown in patients with acute ischemic stroke and treatment with mechanical thrombectomy.•Thin slices (=  1 mm) had the highest clinical utility in comparison with thicker slices (2–10 mm) by having the strongest correlation...
Source: European Radiology - Category: Radiology Source Type: research
Publication date: Available online 25 May 2020Source: Academic RadiologyAuthor(s): Amel Amalou, Baris Turkbey, Sheng Xu, Evrim Turkbey, Peng An, Gianpaolo Carrafiello, Anna Maria Ierardi, Robert Suh, Hayet Amalou, Bradford J. Wood
Source: Academic Radiology - Category: Radiology Source Type: research
Publication date: Available online 24 May 2020Source: International Journal of PharmaceuticsAuthor(s): Ľubica Vetráková, Vilém Neděla, Jiří Runštuk, Eva Tihlaříková, Dominik Heger, Evgenyi Shalaev
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Publication date: August 2020Source: Cancer Epidemiology, Volume 67Author(s): Nicolas R. Smoll, John D. Mathews, Katrina J. Scurrah
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
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Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
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