High tumor stroma proportion is a worse prognostic factor in colorectal cancer.
HIGH TUMOR STROMA PROPORTION IS A WORSE PROGNOSTIC FACTOR
IN COLORECTAL CANCER.
Acta Clin Croat. 2017 03;56(1):73-9
Authors: Flam J, Gugić D, Benšić M, Tomić S, Rajc J
Abstract
High stroma proportion appears to be a very important prognostic factor in
esophageal and breast cancer. Previous researches have shown that it might have a similar effect on
colorectal cancer. The aim of this study was to determine whether tumor stroma proportion influenced
patient survival. This retrospective study included 236 patients with colorectal cancer having undergone
surgery in 2006 and 2007 at Osijek University Hospital Center. Location with the highest
stroma proportion at the site of deepest tumor invasion was determined. Patients were divided into the
groups with high stroma proportion (>50%) and low stroma proportion (≤50%). Stroma proportion
showed a statistically significant correlation with tumor stage. Kaplan-Meier survival curves yielded a
statistically significant difference in patient overall survival (Cox ph model p=0.016) and progression-free
survival (Cox ph model, p=0.0188) according to stroma proportion. Study results showed a statistically
significantly shorter overall survival and progression-free survival in patients with high stroma
proportion.
PMID: 29120138 [PubMed - in process]
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
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