Sleep Apnea may increase risk of developing Alzheimer's disease
(American Thoracic Society) Obstructive sleep apnea (OSA) may put elderly people at greater risk of developing Alzheimer's disease (AD), according to new research published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.
Introduction: Increasing clinical studies suggest a potential link between obstructive sleep apnea (OSA) and Alzheimer’s disease (AD). However, the specific role of intermittent hypoxia (IH) and sleep fragmentation (SF), the two main hallmarks of OSA, in the progression of AD is unknown.Methods: Double transgenic AD model mice (APP/PS1; N=31) and their wild type (WT; N=42) littermates were randomly subjected to either IH (40s of room air at 21% O2 and 20s of hypoxic air at 2% O2), SF (30 arousals per hour) or their respective control groups (intermittent room air: RA or sleep control: SC) for 8 weeks. At the end of t...
Conclusions:Uvulopalatopharyngoplasty may have a preventive effect on dementia in patients with OSA.Citation:Cho JH, Suh JD, Han KD, Jung JH, Lee HM. Uvulopalatopharyngoplasty may reduce the incidence of dementia caused by obstructive sleep apnea: National Insurance Service Survey 2007–2014.J Clin Sleep Med. 2018;14(10):1749–1755.
We present how new discoveries from animal models, human sleep experiments, and Alzheimer's disease biomarkers point to an active role of disturbed sleep in dementia pathogenesis. We show preliminary data on how sex, genetics, physical exercise and cognitive reserve can strengthen or weaken the association between obstructive sleep apnea and dementia. We present preliminary results of obstructive sleep apnea treatment, which can slow, stop or reverse neurodegenerative processes accentuated by obstructive sleep apnea, even in individuals already affected by a neurodegenerative disease. We propose future research directions ...
Early intervention to treat sleep disorders such as obstructive sleep apnea may help prevent or delay Alzheimer’s disease.
A new study finds that obstructive sleep apnea is tied to brain structure alterations found in early dementia and that low blood oxygen might be a factor.
CONCLUSIONS: Proteomic biomarkers in participants with cognitive impairment suggest roles for insulin, and vascular signaling pathways, some of which are similar to findings in Alzheimer's disease. A better understanding of the pathogenic mechanisms of CI in OSAS will help focus clinical trials needed in this patient population. PMID: 29968150 [PubMed - as supplied by publisher]
ConclusionsProteomic biomarkers in participants with cognitive impairment suggest roles for insulin, and vascular signaling pathways, some of which are similar to findings in Alzheimer ’s disease. A better understanding of the pathogenic mechanisms of CI in OSAS will help focus clinical trials needed in this patient population.
CONCLUSION: Multimorbidity is associated with preclinical AD imaging markers of neurodegeneration, but not with amyloid. PMID: 29953971 [PubMed - as supplied by publisher]
Conclusion: Multimorbidity is associated with preclinical AD imaging markers of neurodegeneration, but not with amyloid.Dement Geriatr Cogn Disord 2018;45:272 –281
PMID: 29373798 [PubMed - as supplied by publisher]