Sleep Apnea may increase risk of developing Alzheimer's disease

(American Thoracic Society) Obstructive sleep apnea (OSA) may put elderly people at greater risk of developing Alzheimer's disease (AD), according to new research published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news

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Introduction: Increasing clinical studies suggest a potential link between obstructive sleep apnea (OSA) and Alzheimer’s disease (AD). However, the specific role of intermittent hypoxia (IH) and sleep fragmentation (SF), the two main hallmarks of OSA, in the progression of AD is unknown.Methods: Double transgenic AD model mice (APP/PS1; N=31) and their wild type (WT; N=42) littermates were randomly subjected to either IH (40s of room air at 21% O2 and 20s of hypoxic air at 2% O2), SF (30 arousals per hour) or their respective control groups (intermittent room air: RA or sleep control: SC) for 8 weeks. At the end of t...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sleep and control of breathing Source Type: research
Conclusions:Uvulopalatopharyngoplasty may have a preventive effect on dementia in patients with OSA.Citation:Cho JH, Suh JD, Han KD, Jung JH, Lee HM. Uvulopalatopharyngoplasty may reduce the incidence of dementia caused by obstructive sleep apnea: National Insurance Service Survey 2007–2014.J Clin Sleep Med. 2018;14(10):1749–1755.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
We present how new discoveries from animal models, human sleep experiments, and Alzheimer's disease biomarkers point to an active role of disturbed sleep in dementia pathogenesis. We show preliminary data on how sex, genetics, physical exercise and cognitive reserve can strengthen or weaken the association between obstructive sleep apnea and dementia. We present preliminary results of obstructive sleep apnea treatment, which can slow, stop or reverse neurodegenerative processes accentuated by obstructive sleep apnea, even in individuals already affected by a neurodegenerative disease. We propose future research directions ...
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
Early intervention to treat sleep disorders such as obstructive sleep apnea may help prevent or delay Alzheimer’s disease.
Source: ENT Today - Category: ENT & OMF Authors: Tags: Online Exclusives Practice Focus Sleep Medicine alzheimer's disease Source Type: research
A new study finds that obstructive sleep apnea is tied to brain structure alterations found in early dementia and that low blood oxygen might be a factor.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Alzheimer's / Dementia Source Type: news
CONCLUSIONS: Proteomic biomarkers in participants with cognitive impairment suggest roles for insulin, and vascular signaling pathways, some of which are similar to findings in Alzheimer's disease. A better understanding of the pathogenic mechanisms of CI in OSAS will help focus clinical trials needed in this patient population. PMID: 29968150 [PubMed - as supplied by publisher]
Source: Genomics Proteomics ... - Category: Genetics & Stem Cells Authors: Tags: Sleep Breath Source Type: research
ConclusionsProteomic biomarkers in participants with cognitive impairment suggest roles for insulin, and vascular signaling pathways, some of which are similar to findings in Alzheimer ’s disease. A better understanding of the pathogenic mechanisms of CI in OSAS will help focus clinical trials needed in this patient population.
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research
CONCLUSION: Multimorbidity is associated with preclinical AD imaging markers of neurodegeneration, but not with amyloid. PMID: 29953971 [PubMed - as supplied by publisher]
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
Conclusion: Multimorbidity is associated with preclinical AD imaging markers of neurodegeneration, but not with amyloid.Dement Geriatr Cogn Disord 2018;45:272 –281
Source: Dementia and Geriatric Cognitive Disorders - Category: Geriatrics Source Type: research
PMID: 29373798 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
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