'Old' Lungs May Be Good Transplant Options
Title: 'Old' Lungs May Be Good Transplant OptionsCategory: Health NewsCreated: 11/9/2017 12:00:00 AMLast Editorial Review: 11/9/2017 12:00:00 AM
Conclusions: PR in patients with end-stage lung disease awaiting lung transplantation on nocturnal NIV is feasible and is associated with improvements of exercise capacity and quality of life. Furthermore, despite more advanced lung disease, patients treated with NIV have an increased benefit of PR compared to patients without NIV while awaiting lung transplantation.Respiration
ABSTRACT Solid organ transplantation is a significant development in the treatment of chronic kidney, liver, heart and lung diseases. This therapeutic approach has increased patient survival and improved quality of life. New surgical techniques and immunosuppressive drugs have been developed to achieve better outcomes. However, the variety of neurological complications following solid organ transplantation is broad and carries prognostic significance. Patients may have involvement of the central or peripheral nervous system due to multiple causes that can vary depending on time of onset after the surgical procedure, the tr...
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The association of body mass index (BMI) with lung transplant survival remains controversial due to conflicting evidence in the literature. Prior reports have used traditional BMI categories, included patients transplanted before implementation of the lung allocation score (LAS), or are limited by single center experiences. Here, we evaluated the association of individual BMI units with short- and long-term mortality in a large national database following implementation of the LAS.
Adult congenital heart disease (ACHD) prevalence is increasing worldwide with advanced heart failure (HF) as a leading cause of mortality. Limited data are available on durable mechanical circulatory support (MCS) in ACHD patients.
Conclusions The prevalence of depression and severe distress is common among heart transplant recipients. Patients with many comorbidities are at higher risk of psychological indisposition.
Abstract Lung transplantation remains a viable option for patients with endstage pulmonary disease. Despite removing the affected organ and replacing both lungs, the risk of lung malignancies still exists. Regardless of the mode of entry, lung cancer affects the prognosis in these patients and diligence is required. PMID: 29150033 [PubMed - in process]
This study cohort is a healthy subset of the EpiPath cohort, excluding all participants with acute or chronic diseases. With a mediation analysis we examined whether CMV titers may account for immunosenescence observed in ELA. In this study, we have shown that ELA is associated with higher levels of T cell senescence in healthy participants. Not only did we find a higher number of senescent cells (CD57+), these cells also expressed higher levels of CD57, a cell surface marker for senescence, and were more cytotoxic in ELA compared to controls. Control participants with high CMV titers showed a higher number of senes...
Conclusions Our data demonstrated that circulating leukocytes derived from donor lungs, and not circulating proinflammatory cytokines substantially impaired the quality of lung grafts through caspase-1–induced pyroptotic cell death during EVLP. Removing these cells with a LF and/or inhibiting pyroptosis of the cells can be a new therapeutic approach leading to long-term success after lung transplantation.
Conclusions Our findings suggest that MMF is present in the airways of lung transplant patients and might affect the structural integrity of the airway, which needs further investigation and validation in the clinical setting.