Plasma irisin is elevated in type 2 diabetes and is associated with increased E-selectin levels

Irisin is a hormone released mainly from skeletal muscle after exercise which increases adipose tissue energy expenditure. Adipocytes can also release irisin after exercise, acting as a local adipokine to indu...
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Tags: Original investigation Source Type: research

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Publication date: Available online 24 June 2019Source: Saudi Journal of Biological SciencesAuthor(s): Manal Abudawood, Hajera Tabassum, Mir Naiman Ali, Basmah Almaarik, Mohrah Alshaikh, Anas Dhaifallah AlGhamdi, Johara Yahya AlFaifi, Khalil Ibrahim Softa, Samia Sobki, Ali AljohiAbstractType 2 Diabetes Mellitus (T2DM) is the most widely known type of disorder of the endocrine system marked by hyperglycemia resulting either due to deficiency of insulin and or resistance. Persistent hyperglycemia induces oxidative stress and is suggested to play a prominent role in the pathophysiology underlying T2DM. Besides, oxidative stres...
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
Source: Seminars in Immunopathology - Category: Pathology Source Type: research
Condition:   Type 2 Diabetes Treated With Insulin Interventions:   Other: CRx Self-Management Solution;   Other: CRx Remote Care Solution Sponsors:   QuiO;   SHL Medical;   MidMichigan Health Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 24 June 2019Source: Trends in Endocrinology &MetabolismAuthor(s): Jo E. Lewis, Francis J.P. Ebling, Ricardo J. Samms, Kostas TsintzasFibroblast growth factor 21 (FGF21) is a protein highly synthesized in the liver that exerts paracrine and endocrine control of many aspects of energy homeostasis in multiple tissues. In preclinical models of obesity and type 2 diabetes, treatment with FGF21 improves glucose homeostasis and promotes weight loss, and, as a result, FGF21 has attracted considerable attention as a therapeutic agent for the treatment of metabolic syndrome in humans. An improv...
Source: Trends in Endocrinology and Metabolism - Category: Endocrinology Source Type: research
Conclusions: BW gain from the age of 20 years is correlated with diabetic nephropathy in Japanese patients with type 2 diabetes.Kidney Blood Press Res
Source: Kidney and Blood Pressure Research - Category: Urology & Nephrology Source Type: research
(Oxford University Press USA) A new study soon to appear in the Faculty of Public Health's Journal of Public Health, published by Oxford University Press, suggests that air pollution and living in apartment buildings may be associated with an increased risk for dangerous conditions like heart disease, stroke, and type 2 diabetes. This paper is embargoed until midnight EST on June 25.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
Rheum palmatum L. is widely used in traditional Chinese medicine for the treatment of constipation. Here, the therapeutic effects and underlying mechanisms of purified anthraquinone-glycoside preparation from rhubarb (RAGP) on the type 2 diabetes mellitus (T2DM) rats were investigated. After 6 weeks of metformin and RAGP treatment, the weight returned to normal. Fasting blood glucose (FBG), glycated serum protein (GSP), insulin concentration and HOMA-IR index had significantly decreased, and glucagon-like peptide-1 (GLP-1) concentrations had increased. Histological abnormalities in the pancreas and ileum had improved. Thes...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
AbstractDapagliflozin (Forxiga®) is a highly potent, reversible and selective sodium-glucose cotransporter-2 inhibitor indicated worldwide for the treatment of type 2 diabetes (T2D). In the EU, oral dapagliflozin once daily is approved for use as monotherapy (in patients who are intolerant of metformin) and as add-on combination therapy (with other glucose-lowering agents, including insulin) for T2D when diet and exercise alone do not provide adequate glycaemic control. In numerous well-designed clinical studies and their extensions, dapagliflozin as monotherapy and combination therapy with other antihyperglycaemic age...
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
Molecules, Vol. 24, Pages 2327: Anomeric Spironucleosides of β-d-Glucopyranosyl Uracil as Potential Inhibitors of Glycogen Phosphorylase Molecules doi: 10.3390/molecules24122327 Authors: Aggeliki Stathi Michael Mamais Evangelia D. Chrysina Thanasis Gimisis In the case of type 2 diabetes, inhibitors of glycogen phosphorylase (GP) may prevent unwanted glycogenolysis under high glucose conditions and thus aim at the reduction of excessive glucose production by the liver. Anomeric spironucleosides, such as hydantocidin, present a rich synthetic chemistry and important biological function (e.g., inhibition of...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Nature Reviews Nephrology, Published online: 25 June 2019; doi:10.1038/s41581-019-0171-2Inhibitors of sodium–glucose cotransporter 2 (SGLT2) and dipeptidyl peptidase 4 (DPP4) are widely used in patients with type 2 diabetes to improve glycaemic control and reduce cardiovascular risks. Two recent clinical trials, CREDENCE and DELIGHT, demonstrate that these drugs can also slow down the progression of kidney disease in these patients.
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Source Type: research
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