Effects of hypoglycemia on myocardial susceptibility to ischemia –reperfusion injury and preconditioning in hearts from rats with and without type 2 diabetes

Hypoglycemia is associated with increased mortality rate in patients with diabetes. The underlying mechanisms may involve reduced myocardial tolerance to ischemia and reperfusion (IR) or reduced capacity for i...
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Tags: Original investigation Source Type: research

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NEARLY half of newly diagnosed Type 2 diabetes patients were aged under 35, a survey reveals. Despite the life-threatening disease most commonly affecting the over-40s, research indicates young people are most at risk.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Authors: Ikeoka T, Sako A, Kuriya G, Yamashita H, Yasuhi I, Horie I, Ando T, Abiru N, Kawakami A Abstract A 27-year-old woman with a history of gestational diabetes mellitus (GDM) developed type 1 diabetes mellitus (T1D) in the early postpartum period. Women with a history of GDM are at an increased risk of developing T1D, which is rarer than type 2 diabetes mellitus. A postpartum follow-up 75-g oral glucose tolerance test and the measurement of glutamic acid decarboxylase autoantibodies aided in the early detection of T1D in this patient. Careful attention should be paid to women with a history of GDM who exhibit ...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
DIABETES type 2 symptoms can be difficult to spot, and some people may have high blood sugar without even knowing it. Signs of the condition can include a strange feeling in the extremities, including the hands or feet. Are you at risk?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
AbstractObjectiveThe present study compared the therapeutic effects of great curvature plication with duodenal-jejunal bypass (GCP-DJB) and the commonly used sleeve gastrectomy (SG) in rats with type 2 diabetes mellitus (T2DM).MethodsThe rats were randomly divided into three groups: Control group (n = 6), SG group (n = 6), and GCP-DJB group (n = 6). Body weight, daily food intake, fasting blood glucose level, fasting insulin level, insulin resistance index, and fasting serum concentrations of glucagon-like peptide-1 (GLP-1), peptide tyrosine tyrosine (PYY), and bile acid were measu...
Source: Obesity Surgery - Category: Surgery Source Type: research
In conclusion, we have demonstrated AE has benefits to regulate DPP-4 and GLP-1R, to reduce oxidative stress and renal fibrosis, with resultant to improve renal function and prevent diabetic renal damage. Taken together, F2 could be more promising to be developed as adjuvant for diabetic nephropathy.Graphical abstract
Source: Journal of Food and Drug Analysis - Category: Food Science Source Type: research
(Natural News) Based on research that was presented at the American College of Cardiology‘s 67th Annual Scientific Session, individuals who have both Type 2 diabetes and heart failure, and take an aspirin daily, seem to have a lower risk of dying or being hospitalized for heart failure. But surprisingly enough, the data showed that the intake...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Publication date: Available online 14 August 2018Source: Neurochemistry InternationalAuthor(s): Lindsay Joy Spielman, Deanna Lynn Gibson, Andis KlegerisAbstractThe number of bacterial cells living within the human body is approximately equal to, or greater than, the total number of human cells. This dynamic population of microorganisms, termed the human microbiota, resides mainly within the gastrointestinal tract. It is widely accepted that highly diverse and stable microbiota promote overall human health. Colonization of the gut with maladaptive and pathogenic microbiota, a state also known as dysbiosis, is associated wit...
Source: Neurochemistry International - Category: Neuroscience Source Type: research
DIABETES type 2 risk could be lowered by making some diet or lifestyle changes. Drinking water is an easy way to avoid high blood sugar symptoms, but how much should you be drinking every day?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
The t-SNARE protein SNAP23 conventionally functions as a component of the cellular machinery required for intracellular transport vesicle fusion with target membranes and has been implicated in the regulation of fasting glucose levels, BMI, and type 2 diabetes. Surprisingly, we observed that adipocyte-specific KO of SNAP23 in mice resulted in a temporal development of severe generalized lipodystrophy associated with adipose tissue inflammation, insulin resistance, hyperglycemia, liver steatosis, and early death. This resulted from adipocyte cell death associated with an inhibition of macroautophagy and lysosomal degradatio...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
ConclusionsIn patients with T2D and persistent microalbuminuria, u-KIM-1, but not u-NGAL, was an independent risk factor for decline in eGFR, CVE and all-cause mortality, and contributed significant discrimination for all-cause mortality, beyond traditional risk factors.
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
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