Effect of rosuvastatin on fasting and postprandial endothelial biomarker levels and microvascular reactivity in patients with type 2 diabetes and dyslipidemia: a preliminary report

The cardiovascular benefits of statins have been proven, but their effect on circulation in small vessels has not been examined fully. We investigated the effect of 20  mg rosuvastatin on biomarkers, including ...
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Tags: Original investigation Source Type: research

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Conclusions: Compared with 1996, participants entering CR in 2015 were older, more overweight, and had a higher prevalence of coronary risk factors. Lipid values improved substantially concurrent with increased statin use. While the percentage of female participants increased, they continue to be underrepresented. Patients with heart valve repair/replacement now constitute 10.6% of the patients enrolled. Clinical programs need to recognize changing characteristics of attendees to best tailor interventions.
Source: Journal of Cardiopulmonary Rehabilitation - Category: Rehabilitation Tags: Cardiac Rehabilitation Source Type: research
Listen to critics of the Wheat Belly lifestyle and you’d think that, by banishing all things wheat and grains from your life, you will be excommunicated from your church, tossed out of your club, ostracized by friends and family, and suffer dire health consequences like heart disease and colon cancer. After all, they say that you are eliminating an entire food group and will be crippled by lack of fiber and nutrients. Worse, our focus on increasing our intake of fats and oils will get you a heart attack, three stents, or bypass surgery and you’ll be obliged to take Lipitor and Repatha for a lifetime. First of a...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle grain-free Weight Loss Source Type: blogs
AbstractPurpose of ReviewNon-dialysis-dependent chronic kidney disease (NDD-CKD) patients are at an increased risk of cardiovascular disease (CVD) –related deaths in comparison with the general population. This review summarizes recent guideline recommendations and studies on primary and secondary prevention of traditional cardiovascular (CV) risk factors in those with NDD-CKD.Recent FindingsThe use of antiplatelet agents for primary prevention in CKD is not supported by clinical trial evidence; however, they offer potential benefits when used for secondary prevention of CVD in the absence of an elevated bleeding ris...
Source: Current Atherosclerosis Reports - Category: Cardiology Source Type: research
Supplementation not associated with reduced risks of CVD events or all-cause mortality in meta-analysis Related items fromOnMedica Coronary heart disease remains UK ’s biggest killer NICE says far more people should take statins Type 2 diabetes in 10 times more young people than realised Sugar not saturated fat is the major issue for CVD Physical activity might offset harms of time spent sitting
Source: OnMedica Latest News - Category: UK Health Source Type: news
Large international study explores role of dulaglutide Related items fromOnMedica Statin use link to heightened type 2 diabetes risk in some people Diabetes prescriptions rise by a third in last five years US expert group updates statins recommendations Drug could cut heart events by 26% in diabetics Metformin doesn ’t help HbA1c in teens with type 1 diabetes
Source: OnMedica Latest News - Category: UK Health Source Type: news
Drug delays diabetes onset a median of 2 years Related items fromOnMedica Statin use link to heightened type 2 diabetes risk in some people Type 2 diabetes drugs vary in impact on survival NICE approves extra ‘triple therapy’ drug for diabetes Study claims medical treatment can reverse type 2 diabetes Drug could cut heart events by 26% in diabetics
Source: OnMedica Latest News - Category: UK Health Source Type: news
Abstract BACKGROUND: Anthocyanin-rich blueberry intake is associated with reduced type 2 diabetes and cardiovascular disease (CVD) risk in prospective studies, although long-term randomized controlled trials (RCTs) have not been conducted in at-risk populations. OBJECTIVE: In the longest-duration RCT to date, we examined the effect of 6-mo blueberry intake on insulin resistance and cardiometabolic function in metabolic syndrome. METHODS: A double-blind, parallel RCT (n = 115; age 63 ± 7 y; 68% male; body mass index 31.2 ± 3.0 kg/m2) was conducted, which fed 2 d...
Source: The American Journal of Clinical Nutrition - Category: Nutrition Authors: Tags: Am J Clin Nutr Source Type: research
 The World Health Organization's latestguideline on risk reduction of cognitive decline and dementia has been published. This guideline provides global, evidence-informed recommendations on how to reduce the risk of cognitive decline and dementia.It features evidence from reviews of theCochrane Dementia and Cognitive Improvement group in 3 of the guideline ’s  evidence profiles - Physical activity interventions, Management of diabetes and Management of dyslipidaemia. The featured reviews are:Aerobic exercise to improve cognitive function in older people without known cognitive impairment. Effect of the...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news
In this study, we found that cofilin competes with tau for direct microtubule binding in vitro, in cells, and in vivo, which inhibits tau-induced microtubule assembly. Genetic reduction of cofilin mitigates tauopathy and synaptic defects in Tau-P301S mice and movement deficits in tau transgenic C. elegans. The pathogenic effects of cofilin are selectively mediated by activated cofilin, as active but not inactive cofilin selectively interacts with tubulin, destabilizes microtubules, and promotes tauopathy. These results therefore indicate that activated cofilin plays an essential intermediary role in neurotoxic signaling th...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionsNo evidence of an association between the use of metformin or statins and the incidence of breast cancer in women with T2D was found. Among insulin users, a slightly higher incidence of breast cancer was observed.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
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