' Old' Lungs May Be Good Transplant Options

THURSDAY, Nov. 9, 2017 -- Lungs from older donors are a viable option for lung transplants and should be considered more often, a new study suggests. Survival rates for younger recipients of lung transplants from donors older than 60 are similar to...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news

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AbstractSummaryPatients with cystic fibrosis awaiting lung transplantation for end-stage respiratory failure have high prevalence of reduced bone mineral density and fragility fracture. Suboptimal 25-hydroxyvitamin D levels could significantly contribute to the development of cystic fibrosis-related bone disease.IntroductionThe assessment of the prevalence of cystic fibrosis-related bone disease (CFBD) and its associated risk factors in young adults with cystic fibrosis (CF) awaiting lung transplantation for end-stage respiratory failure.MethodsClinical characteristics, bone mineral density (BMD), the parameters of calcium...
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
an MK Abstract RATIONALE: Evidence suggests damage to small airways is a key pathologic lesion in chronic obstructive pulmonary disease (COPD). Computed Tomography (CT) densitometry has been demonstrated to identify emphysema, but no such studies have been performed linking an imaging metric to small airway abnormality. OBJECTIVES: To correlate ex vivo Parametric Response Mapping (PRM) analysis to in vivo lung tissue measurements of patients with severe COPD treated by lung transplantation and controls. METHODS: Resected lungs were inflated, frozen, and systematically sampled, generating 33 COPD (n=11 su...
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
Conditions:   Lung Transplantation;   Chronic Lung Allograft Dysfunction;   Rejection Lung Transplant Intervention:   Other: Early detection of CLAD by Lung Clearance Index (LCI) Sponsor:   University of Zurich Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionCLAD, especially RAS, appears to develop later after LDLLT than after CLT and seems to have a lower impact on the overall survival after LDLLT than that after CLT.
Source: Surgery Today - Category: Surgery Source Type: research
The implementation of effective prevention strategies has significantly reduced the incidence of cytomegalovirus (CMV) pneumonia after allogeneic hematopoietic stem transplantation (allo-HSCT)1; nevertheless, this clinical entity persists as a major clinical problem owing to poor survival, despite timely initiation of targeted antiviral therapy.1,2 Currently, diagnosis of CMV pneumonia still remains a challenge. Proven CMV pneumonia can only be diagnosed using virological, histopathological or immunochemistry methods on biopsied lung tissue1; this specimen type, however, is rarely obtained due to potential life-threatening complications.
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research
PMID: 30785776 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
Cystic fibrosis liver disease (CFLD) remains the third leading cause of death in patients with cystic fibrosis. Although most patients with CFLD present in childhood, recent studies suggest a second wave of liver disease in adulthood. There are no clear guidelines for diagnosing CFLD. Treatment options for CFLD remain limited, and while UDCA is widely used, its long-term benefit is unclear. Those who develop hepatic decompensation or uncontrolled variceal bleeding may benefit from liver transplant, either alone, or in combination with lung transplant.
Source: Clinics in Liver Disease - Category: Gastroenterology Authors: Source Type: research
CONCLUSION: Our results suggest that ESS is associated with a reduction in the frequency of antibiotic utilization for respiratory tract infections in lung transplant recipients with CF. A prospective study is needed to investigate these relationships further. PMID: 30781973 [PubMed - as supplied by publisher]
Source: American Journal of Rhinology and Allergy - Category: ENT & OMF Authors: Tags: Am J Rhinol Allergy Source Type: research
AbstractAimsPatients with heart failure (HF) are known to have a reduced pulmonary diffusion capacity for carbon monoxide (DLCO), but little is known about how lung function relates to central haemodynamics. The aim of this study was to investigate the association between haemodynamic variables and pulmonary diffusion capacity adjusted for alveolar volume in congestive HF patients and to analyse how predicted DLCO/VA affects mortality in relation to the haemodynamic status.Methods and resultsWe retrospectively studied right heart catheterization (RHC) and lung function data on 262 HF patients (mean age 51  ±&nb...
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research
We have read with great interest the case report by Pujol et al entitled Synchronous multiple non-small cell lung cancers in an allograft lung recipient [1], about a young cystic fibrosis lung transplant recipient who developed metastatic lung cancer. We would like to comment on this ‘rare’ long-term complication post lung transplantation. Recent registry data from the International Society of Heart and Lung Transplantation showed that the overall incidence of a malignancy post lung transplantation at 1, 5 and 10 years is 5.3%, 19.6% and 31.7% respectively [2] In observation al studies the incidence of lung can...
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
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