Neonatal Graves' Disease with Maternal Hypothyroidism
We present a unique case of neonatal Graves' disease in a premature infant with conjugated hyperbilirubinemia born to a mother with hypothyroidism during pregnancy and remote history of Graves' disease. Infant was treated with a combination of methimazole, propranolol, and potassium iodide for 4 weeks. Thyroid function improved after 8 weeks of treatment with full recovery of thyroid function, disappearance of thyroid-stimulating antibodies, and resolution of failure to thrive and conjugated hyperbilirubinemia. This case provides several clinical vignettes as it is a rare, severe, presentation of an uncommon neonatal disease, signs, symptoms, and clinical history presented a diagnostic challenge for neonatologists and endocrinologists, normal newborn screen was misleading, and yet timely treatment led to a full recovery. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents | Abstract | open access Full text
Source: American Journal of Perinatology Reports - Category: Perinatology & Neonatology Authors: Akangire, Gangaram Cuna, Alain Lachica, Charisse Fischer, Ryan Raman, Sripriya Sampath, Venkatesh Tags: Case Report Source Type: research
More News: Endocrinology | Hypothyroidism | Inderal | Liver | Perinatology & Neonatology | Potassium | Pregnancy | Thyroid | Urology & Nephrology