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MRI shows possible link between blood flow, Alzheimer's

MRI scans have confirmed reduced blood flow in key regions of the brain associated...Read more on AuntMinnie.comRelated Reading: MRI measures brain atrophy in Alzheimer's MRI uncovers evidence on Alzheimer's origins ASL-MRI detects early signs of cognitive decline in elderly MRI finds loss of brain volume in older, apathetic adults 4T fMRI sheds light on brain activity in early Alzheimer's
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news

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AbstractThere is an urgent need for identifying nondemented individuals at the highest risk of progressing to Alzheimer ’s disease (AD) dementia. Here, we evaluated whether a recently validated polygenic hazard score (PHS) can be integrated with known in vivo cerebrospinal fluid (CSF) or positron emission tomography (PET) biomarkers of amyloid, and CSF tau pathology to prospectively predict cognitive and clinical d ecline in 347 cognitive normal (CN; baseline age range = 59.7–90.1, 98.85% white) and 599 mild cognitively impaired (MCI; baseline age range = 54.4–91.4, 98.83% white) indiv...
Source: Acta Neuropathologica - Category: Neurology Source Type: research
Conclusions: Dementia with Lewy bodies patients may harbor 18F‐AV‐1451 binding patterns distinct from Alzheimer's disease, with greater involvement of the primary cortices and less involvement of the temporal cortex. Tau burden increases in the Lewy body disease spectrum, and amyloid may play an important role in the accumulation of neocortical tau in Lewy body diseases. © 2017 International Parkinson and Movement Disorder Society
Source: Movement Disorders - Category: Neurology Authors: Tags: Research Article Source Type: research
Publication date: 15 February 2018 Source:NeuroImage, Volume 167 Author(s): Frank de Vos, Marisa Koini, Tijn M. Schouten, Stephan Seiler, Jeroen van der Grond, Anita Lechner, Reinhold Schmidt, Mark de Rooij, Serge A.R.B. Rombouts Alzheimer's disease (AD) patients show altered patterns of functional connectivity (FC) on resting state functional magnetic resonance imaging (RSfMRI) scans. It is yet unclear which RSfMRI measures are most informative for the individual classification of AD patients. We investigated this using RSfMRI scans from 77 AD patients (MMSE = 20.4 ± 4.5) and 173 controls (MMSE...
Source: NeuroImage - Category: Neuroscience Source Type: research
Objective: To test the hypothesis that cortical and hippocampal volumes, measured in vivo from volumetric MRI (vMRI) scans, could be used to identify variant subtypes of Alzheimer disease (AD) and to prospectively predict the rate of clinical decline. Methods: Amyloid-positive participants with AD from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) 1 and ADNI2 with baseline MRI scans (n = 229) and 2-year clinical follow-up (n = 100) were included. AD subtypes (hippocampal sparing [HpSpMRI], limbic predominant [LPMRI], typical AD [tADMRI]) were defined according to an algorithm analogous to one recently propo...
Source: Neurology - Category: Neurology Authors: Tags: MRI, Alzheimer's disease ARTICLE Source Type: research
We examined spreading disease in non-amnestic Alzheimer's disease using a novel magnetic resonance imaging-based analysis adapted from pathologic staging studies, applied here to cross-sectional imaging data. We selected 240 T1-weighted scans from 129 patients with pathology confirmed by autopsy or cerebrospinal fluid, and atrophy maps were computed relative to 238 scans from 115 elderly controls.
Source: Neurobiology of Aging - Category: Neuroscience Authors: Source Type: research
Based on a brain autopsy using PET with the radiopharmaceutical FDDNP, researchers...Read more on AuntMinnie.comRelated Reading: MRI shows promise in diagnosing CTE in living patients FDDNP-PET gives insight into brain trauma of NFL players FDDNP-PET shows toll of concussions on retired NFL players FDDNP-PET helps predict Alzheimer's progression PET with FDDNP helps find depression cause
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Researchers at Lund University in Sweden have for the first time shown where in the brain the earliest signs of Alzheimer's occur.ByAlzheimer's Reading RoomThe discovery could potentially become significant to future Alzheimer's research while contributingto improved diagnostics."A big piece of the puzzle in Alzheimer's research is now falling into place."We did not know where in the brain the earliest stages of the disease could be detected.We now know which parts of the brain are to be studied to eventually explain why the disease occurs."What is the Difference Between Alzheimer ’s and DementiaSubscr...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: Alzheimers Dementia alzheimers research alzheimersreadingroom brain brain test health memory loss memory test science Source Type: blogs
DISCUSSION: Patients and caregivers supported the use of amyloid PET imaging in clinical practice and felt that the information would provide significant benefits particularly in terms of future planning. PMID: 29140859 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
Should James Clement's name remain well-known in association any of the present day work on human longevity, one would hope it will be as one of the pioneers to first organize trials of senolytic therapies in humans, via his Betterhumans organization. This is far from the only research interest of this citizen scientist, however, and in past years he has put in a great deal of time and effort to expand what is known of the genetics and biochemistry of supercentenarians, rare individuals who survive past the age of 110. That is the focus of the article here. For my part I think that the genetics of supercentenarians ...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Editor —We read with great interest the recent editorial by Aranake-Chrisinger&Avidan.1 We were pleased to see that this editorial contains terminology developed over several yr by the multi-disciplinary International Perioperative Cognition Nomenclature Working Group. At the same time, we were surprised and disappointed that the terminology is presented before the official release (in theBritish Journal of Anaesthesia as well as Anesthesia&Analgesia, Canadian Journal of Anesthesiology, Acta Anaesthesiologica Scandinavica, Journal of Alzheimers Disease and Anesthesiology),2 without the necessary definitions o...
Source: British Journal of Anaesthesia - Category: Anesthesiology Source Type: research
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