In vitro analysis of antispasmodic activity of ethanolic stem extracts of Uvaria rufa Blume and Anomianthus dulcis (Dunal) J. Sinclair on excised rat ’s ileum

AbstractIrritable bowel syndrome (IBS) is a symptom of functional gastrointestinal disorders. It is commonly experienced as abdominal cramp, diarrhea, and constipation. The diagnosis and treatment of IBS were mostly conducted by synthetic medicines including antispasmodic drugs that have many side effects and are so expensive. The aim of the present study was to explore the antispasmodic activity ofUvaria rufa Blume andAnomianthus dulcis (Dunal) J. Sinclair extracts on isolated rats ’ ilia which later compared to atropine as reference drug. The ethanolic extracts from the stem ofA. dulcis andU. rufa were investigated for their antispasmodic activities against acetylcholine-induced rats ’ ilia contraction in vitro experiment. The results of this study showed that both ethanolic extracts ofU. rufa andA. dulcis have an antispasmodic efficiency at all concentrations of 200, 300, 400, and 500  μg/ml on excised rats’ ilia. They produced the highest relaxation of 92.71 ± 5.97 and 98.53 ± 0.61% inA. dulcis andU. rufa extracts, respectively, while atropine produced 112.84  ± 5.61% at concentration of 10.0 μg/ml. These results suggest thatU. rufa andA. dulcis could be used as antispasmodic agents for IBS treatment.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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Source: JAMA - Journal of the American Medical Association - Category: General Medicine Source Type: research
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Source: Journal of Pharmacy and Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Review Source Type: research
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Source: Diabetes Therapy - Category: Endocrinology Source Type: research
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Source: Acta medica Indonesiana - Category: Internal Medicine Tags: Acta Med Indones Source Type: research
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Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
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Source: - Category: Consumer Health News Source Type: news
Conditions:   Anismus;   Distal Constipation Interventions:   Device: Anal EndoFLIP®;   Diagnostic Test: Anal Manometry;   Diagnostic Test: Defecography;   Diagnostic Test: Electromyogram Sponsor:   University Hospital, Rouen Not yet recruiting
Source: - Category: Research Source Type: clinical trials
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