Sodium Oxybate Promising for Parkinson ’ s, Daytime Sleepiness

Improvements in subjective sleep quality, objectively measured slow - wave sleep duration
Source: Pulmonary Medicine News - Doctors Lounge - Category: Respiratory Medicine Tags: Family Medicine, Geriatrics, Internal Medicine, Neurology, Pharmacy, Pulmonology, Journal, Source Type: news

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We report a patient with GD type 1 who was diagnosed with corticobasal syndrome (CBS), a clinical atypical parkinsonism diagnosis, in his sixth decade of life. Our case highlights the need to consider forms of atypical parkinsonism such as CBS in addition to PD in the differential diagnosis of cognitive and motor changes in patients with GD type 1. We also recommend careful assessment and routine monitoring of cognition, mood, behavior, sleep patterns, olfaction, and memory in patients with GD type 1 to identify early symptoms indicative of neurological involvement.
Source: Molecular Genetics and Metabolism Reports - Category: Genetics & Stem Cells Source Type: research
Annals of Neurology,Volume 0, Issue ja, -Not available-.
Source: Annals of Neurology - Category: Neurology Authors: Source Type: research
AbstractPurpose of ReviewParkinson ’s disease was studied for a long time from the prism of a motor impairment. Recent advances have outlined the importance of cognitive and neuropsychiatric symptoms (NPS) in the PD equation. This review concentrates on the present possibilities of using neuroimaging techniques in order to quantify the cognitive performance and NPS in PD patients.Recent FindingsMild cognitive impairment as well as many NPS have been acknowledged as important criteria for assessing the quality of life in patients with Parkinson ’s disease and have been shown as potential factors in predicting fu...
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research
Conclusions:In FTDP-17, striatum and brainstem are the pathological lesions, which may be involved in the pathophysiology of the alterations in sleep architecture. The concrete mechanisms need further investigation.Citation:Liu J, Zhan S, Huang C, Liu Y, Liu L, Wu L, Wang Y. Sleep architecture changed without RBD in patients with FTDP-17.J Clin Sleep Med. 2018;14(10):1735–1739.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
Sleep disturbances are common across the stages of Parkinson's disease and increase with disease progression. A study suggests that because there is little overlap, they may have different etiologies.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Family Medicine/Primary Care News Source Type: news
Publication date: 2018Source: International Review of Neurobiology, Volume 141Author(s): Nicolaas I. Bohnen, Prabesh Kanel, Martijn L.T.M. MüllerAbstractOne of the first identified neurotransmitters in the brain, acetylcholine, is an important modulator that drives changes in neuronal and glial activity. For more than two decades, the main focus of molecular imaging of the cholinergic system in Parkinson's disease (PD) has been on cognitive changes. Imaging studies have confirmed that degeneration of the cholinergic system is a major determinant of dementia in PD. Within the last decade, the focus is expanding to stud...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
Publication date: 2018Source: International Review of Neurobiology, Volume 141Author(s): Gennaro Pagano, Marios PolitisAbstractIn the last decades, the main focus of molecular imaging of Parkinson's disease has been on non-dopaminergic systems involved in the disease alongside the pathognomonic dopaminergic changes. Molecular imaging can detect, in vivo, both presynaptic and postsynaptic serotonergic changes in the brain and has played a key role in elucidating the pathophysiology of the serotonergic system in Parkinson's disease. Alterations in the serotonergic system may happen very early in the course of the disease and...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
CONCLUSIONS: Eszopiclone appears to be an efficient drug with moderate effects on sleep onset and maintenance. There was no or little evidence of harm if taken as recommended. However, as certain patient subgroups were underrepresented in RCTs included in the review, findings might not have displayed the entire spectrum of possible adverse events. Further, increased caution is required in elderly individuals with cognitive and motor impairments and individuals who are at increased risk of using eszopiclone in a non-recommended way. PMID: 30303519 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
za EM Abstract Mutations in the PINK1 gene are responsible for typical symptoms of Parkinson's disease. Using Drosophila melanogaster mutant PINK1B9 and after PINK1 silencing with RNAi using transgenic lines, we observed defects in synapses and behavior. The lack or reduced expression of PINK1 prolonged sleep during the day (nap) and decreased the total locomotor activity during 24 h, in addition to a decrease in climbing ability and a reduced lifespan. In the brain, PINK1 mutants had a lower level of Bruchpilot (BRP), a presynaptic scaffolding protein that is crucial for neurotransmission in all type of synapses ...
Source: Acta Neurobiologiae Experimentalis - Category: Neurology Authors: Tags: Acta Neurobiol Exp (Wars) Source Type: research
ConclusionThese findings indicate that CSF A β1 –42 level is associated with global cognitive decline in early PD with RBD. The addition of CSF A β1 –42 to RBD testing increase the likelihood of identifying those at high risk for cognitive decline in early PD.
Source: Translational Neurodegeneration - Category: Neurology Source Type: research
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