Sodium Oxybate Promising for Parkinson ’ s, Daytime Sleepiness

Improvements in subjective sleep quality, objectively measured slow - wave sleep duration
Source: Pulmonary Medicine News - Doctors Lounge - Category: Respiratory Medicine Tags: Family Medicine, Geriatrics, Internal Medicine, Neurology, Pharmacy, Pulmonology, Journal, Source Type: news

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ConclusionsMMBCEP, a complex exercise program-based on mindfulness meditation, is associated with increased motor symptoms, decreased emotional disturbances (anxiety and depression) and sleep disturbance, and improved cognitive functions, quality of life, and activities of daily living. Future research should test the effects of MMBCEP with more representative PD patients.
Source: Asian Nursing Research - Category: Nursing Source Type: research
Publication date: July 2018Source: The Lancet Neurology, Volume 17, Issue 7Author(s): Karoline Knudsen, Tatyana D Fedorova, Allan K Hansen, Michael Sommerauer, Marit Otto, Kristina B Svendsen, Adjmal Nahimi, Morten G Stokholm, Nicola Pavese, Christoph P Beier, David J Brooks, Per BorghammerSummaryBackgroundAccumulating evidence suggests that α-synuclein aggregates—a defining pathology of Parkinson's disease—display cell-to-cell transmission. α-synuclein aggregation is hypothesised to start in autonomic nerve terminals years before the appearance of motor symptoms, and subsequently spread via autonom...
Source: The Lancet Neurology - Category: Neurology Source Type: research
Publication date: July 2018Source: The Lancet Neurology, Volume 17, Issue 7Author(s): Katharina A Schindlbeck, David EidelbergSummaryParkinson's disease presents several practical challenges: it can be difficult to distinguish from atypical parkinsonian syndromes, clinical ratings can be insensitive as markers of disease progression, and its non-motor manifestations are not readily assessed in animal models. These challenges, along with others, are beginning to be addressed by innovative imaging methods to characterise Parkinson's disease-specific functional networks across the whole brain and measure their expression in e...
Source: The Lancet Neurology - Category: Neurology Source Type: research
In this study, we assessed the relationships between motor symptoms and sleep quality in 29 PD patients (17 PD patients reporting impaired bed mobility (IBM) and 12 patients without IBM). All the participants were monitored using multisite inertial sensors and polysomnography in sleep-monitoring rooms for whole night. Compared with PD−IBM patients, PD+IBM patients tended to have fewer turning-over episodes and smaller degree turns. Meanwhile, PD+IBM patients had worse Pittsburgh Sleep Quality Index (PSQI) and Parkinson’s Disease Sleep Scale (PDSS) scores, and less total sleep time (TST) than PD−IBM patien...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
ConclusionsWe found that DBS-STN improved quality of life, subjective quality of sleep and sleepiness, however, contrary to the previous studies the objective parameters of sleep worsened after the surgery.
Source: Polish Journal of Neurology and Neurosurgery - Category: Neurosurgery Source Type: research
AbstractSleep dysfunctions, including rapid eye movement sleep behavior disorder, sleep fragmentation, excessive daytime sleepiness and various other dysfunctions, can seriously affect quality of life in patients with Parkinson ’s disease (PD). Emerging evidence suggests that deep brain stimulation (DBS) exerts a substantial effect when used to treat sleep dysfunctions, which are common nonmotor symptoms experienced by patients with PD. However, far less is known about the specific mechanisms underlying the effects of DB S on sleep processes and the factors that potentially influence these effects. These issues there...
Source: Acta Neurologica Belgica - Category: Neurology Source Type: research
Dream enacting behavior (DEB) during REM sleep is a characteristic feature of REM sleep behavior disorder (RBD), the most specific prodromal symptom for Parkinson's disease (PD) and related synucleinopathies.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research
ConclusionsMMBCEP, a complex exercise program-based on mindfulness meditation, is associated with increased motor symptoms, decreased emotional disturbances (anxiety and depression) and sleep disturbance, and improved cognitive functions, quality of life, and activities of daily living. Future research should test the effects of MMBCEP with more representative PD patients.
Source: Asian Nursing Research - Category: Nursing Source Type: research
ConclusionsWe found that DBS-STN improved quality of life, subjective quality of sleep and sleepiness, however, contrary to the previous studies the objective parameters of sleep worsened after the surgery.
Source: Polish Journal of Neurology and Neurosurgery - Category: Neurosurgery Source Type: research
AbstractParkinson ’ disease (PD) is characterized by motor symptoms including bradykinesia, resting tremor, postural instability, and rigidity and non-motor symptoms such as cognitive impairment, sleep disorder, and depression. Neuroinflammation has been recently implicated in pathophysiology of both motor and non- motor symptoms of PD. One of the most notable inflammatory proteins is C-reactive protein (CRP), which is elevated in the conditions of systemic inflammation. Using BioFIND database, we scrutinized the possible association between cerebrospinal fluid (CSF) levels of CRP and severity of PD motor and non-mot...
Source: NeuroMolecular Medicine - Category: Neurology Source Type: research
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