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Sodium Oxybate Promising for Parkinson ’ s, Daytime Sleepiness

Improvements in subjective sleep quality, objectively measured slow - wave sleep duration
Source: Pulmonary Medicine News - Doctors Lounge - Category: Respiratory Medicine Tags: Family Medicine, Geriatrics, Internal Medicine, Neurology, Pharmacy, Pulmonology, Journal, Source Type: news

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Major depressive disorder and social anxiety disorder lead to abnormal modifications...Read more on AuntMinnie.comRelated Reading: fMRI reveals that 'magic mushrooms' reduce depression fMRI links brain disruptions to Parkinson's hallucinations fMRI locates brain region tied to sleep-related depression fMRI scans may help choose depression treatment strategy fMRI shows emotional areas of brain
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Authors: Bassetti CL, Bargiotas P Abstract Rapid eye movement sleep behavior disorder (RBD) is a brain disorder, characterized by the dream enactment during rapid eye movement (REM) sleep due to a lack of physiologic muscle atonia and increased muscle twitching. Schenk was the first to describe this disorder in 1986; however, few authors reported in the 1970-1980s loss of physiological muscle atonia combined with dream enactment in the course of brainstem disorders and as a consequence of alcoholism and antidepressant treatment. RBD affects less than 1% of the adult population, but can be found in up to 25-50% of n...
Source: Frontiers of Neurology and Neuroscience - Category: Neuroscience Tags: Front Neurol Neurosci Source Type: research
Parasomnias and sleep-related movement disorders are important problems in older adults. Sleep paralysis is rare, but may occur in families. In a minority of patients with disorders of arousal, the episodes persist until the age of 70. Zolpidem and other medications may induce sleepwalking and sleep-related eating. Most patients with idiopathic rapid eye movement (REM) sleep behavior disorder eventually develop Parkinson ’s disease or dementia with Lewy bodies. Anti-IgLON5 disease includes abnormal behaviors in NREM and REM sleep. Restless legs syndrome prevalence increases with age. A severe form of periodic limb mo...
Source: Sleep Medicine Clinics - Category: Sleep Medicine Authors: Source Type: research
To evaluate whether Continuous Positive Airway Pressure treatment (CPAP) affect autonomic nervous system (ANS) in patients with severe obstructive sleep apnea (OSAS). We compared de novo OSAS patients, OSAS patients on chronic CPAP treatment and controls using the Scales for Outcome in Parkinson disease-Autonomic (SCOPA-AUT) questionnaire. All groups underwent autonomic function tests including head-up tilt test (HUTT), Valsalva maneuver, deep breathing, handgrip and cold face test. Twelve untreated OSAS, 17 OSAS on CPAP and 14 controls were studied.
Source: Clinical Neurophysiology - Category: Neuroscience Authors: Source Type: research
ConclusionsApathy is common in RBD and is underestimated by a single self‐report question. Recognition of apathy as a distinct neuropsychiatric feature in RBD could aid targeted treatment interventions and might contribute to understanding of prodromal Parkinson's disease.This article is protected by copyright. All rights reserved.
Source: European Journal of Neurology - Category: Neurology Authors: Tags: Original Article Source Type: research
Abstract Cognitive impairment is an important non-motor symptom of Parkinson's disease (PD). The neuronal death in nigrostriatal pathway is the main factor for motor symptoms and recent studies indicate a possible influence in non-motor symptoms as well. The pedunculopontine tegmental nucleus (PPT) and basal ganglia are closely related anatomically and functionally and, since they are affected by neurodegeneration in PD, they might be involved in recognition memory. To investigate this, we promoted an ibotenic acid lesion within the PPT or a rotenone lesion within substantia nigra pars compacta (SNpc) of Wistar ra...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research
This randomized clinical trial evaluates the effect of sodium oxybate in treatment of debilitating excessive daytime sleepiness and disturbed nighttime sleep in patients with Parkinson disease.
Source: JAMA Neurology - Category: Neurology Source Type: research
In functional stereotactic neurosurgery, precise placement of lesions or deep brain stimulation (DBS) electrodes is paramount. From the beginning of the specialty, electrical stimulation of the brain target prior to lesioning, and confirmation of accuracy of targeting by postoperative imaging, have been critical.1 Two schools subsequently evolved: one using macroelectrode stimulation in the awake patient with careful on-table assessment and one using microelectrode recording (MER) to map out boundaries of the target followed by microstimulation to assess efficacy and avoid side effects. For many, the latter technique was a...
Source: Neurology - Category: Neurology Authors: Tags: EDITORIALS Source Type: research
Publication date: Available online 6 November 2017 Source:Journal of Clinical Neuroscience Author(s): Yoon Kim, Young Eun Kim, Eun Ok Park, Chae Won Shin, Han-Joon Kim, Beomseok Jeon REM sleep behavior disorder (RBD) is a parasomnia wherein a loss of REM sleep atonia manifests as dream-enactment, often violent. Aside from its significance as a predictor of PD, RBD in PD may imply more than merely screaming at night and experiencing sleep fragmentation. To probe its significance as a prognostic factor in PD, we performed a systematic literature review. Analysis of prospective studies reveals baseline RBD confers a higher r...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Conclusions: Medical cannabis was found to improve symptoms of PD in the initial stages of treatment and did not cause major adverse effects in this pilot, 2-center, retrospective survey. The extent of use and the reported effects lend support to further development of safer and more effective drugs derived from Cannabis sativa.
Source: Clinical Neuropharmacology - Category: Neurology Tags: Original Articles Source Type: research
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