Immunomodulatory Effects of Tyrosine Kinase Inhibitors (TKIs) in Vitro and in Vivo Study.

• TKIs suppress the production of pro-inflammatory cytokines in vitro, including IL17• TKIs reduce the frequency of total Tregs in vitro but preserve naïve subsets• B and NK cells are impaired by TKIs in vitro, whereas T cells are preserved• Comparable results were obtained in patients trea ted with Nilotinib for cGVHD

http://www.bbmt.org/article/S1083-8791(17)30808-X/fulltext?rss=yes

Source: Biology of Blood and Marrow Transplantation - November 8, 2017 Category: Hematology Authors: Elena MARINELLI BUSILACCHI, Andrea COSTANTINI, Nadia VIOLA, Benedetta COSTANTINI, Jacopo OLIVIERI, Luca BUTINI, Giorgia MANCINI, Ilaria SCORTECHINI, Martina CHIARUCCI, Monica POIANI, Antonella POLONI, Pietro LEONI, Attilio OLIVIERI Source Type: research