Combined Haploidentical and Umbilical Cord Blood Allogeneic Stem Cell Transplantation for High-Risk Lymphoma and CLL

• CD34 selected haploidentical cells are combined with Umbilical Cord Blood (haplo-cord) stem cells as donor source• Rapid neutrophil (median 11 days) and platelet recovery (19 days) is achieved because of the haplo-graft, but durable hematopoiesis resulting from the UCB graft with a very low in cidence of chronic GVHD (8%).• 42 patients with advanced lymphoma or CLL were treated and had 3-year OS, PFS and GRFS of 65%, 62% and 52% respectively.

Source: Biology of Blood and Marrow Transplantation - November 8, 2017 Category: Hematology Authors: Jingmei Hsu, Andrew Artz, Sebastian A. Mayer, Danielle Guarner, Michael R. Bishop, Ronit Reich-Slotky, Sonali M. Smith, June Greenberg, Justin Kline, Rosanna Ferrante, Adrienne A. Phillips, Usama Gergis, Hongtao Liu, Wendy Stock, Melissa Cushing, Tsiporah Source Type: research