Long-term safety of long-acting octreotide in patients with diabetic retinopathy: results of pooled data from 2 randomized, double-blind, placebo-controlled phase 3 studies

ConclusionsThe results from these long-term placebo-controlled studies confirm the established safety profile of long-acting OCT, in particular low risk of cardiac, hepatic and renal toxicity in a high-risk population.
Source: Endocrine - Category: Endocrinology Source Type: research

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CONCLUSIONS The MI-SNP and MII-SNP FSAP gene polymorphisms were not predictive or prognostic biomarkers for CAD or its main risk factors. However, the presence of the MII-SNP polymorphism was associated with a reduced risk of developing CAD. PMID: 29927903 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
ConclusionCollectively, SP can block the loss of therapeutic potential of MSCs by preserving their proliferative and paracrine potential. This study indicates the potential of SP as a supplement in stem cell culture for therapy.
Source: Molecular and Cellular Toxicology - Category: Cytology Source Type: research
AbstractPurpose of reviewTyrosine kinase inhibitors (TKIs) have shown clear survival benefits as effective targeted therapies in various hematological and solid malignancies. Important evidence, however, has shown that TKIs may lead to adverse effects such as cardiovascular toxicities, via off-target as well as on-target mechanisms. This review presents an overview of TKI-induced cardiotoxicity mechanisms, clinical manifestations, diagnosis, monitoring, and management options. Furthermore, we discuss current preclinical efforts and future investigations into alternative therapeutics for minimizing the cardiotoxicities asso...
Source: Molecular and Cellular Toxicology - Category: Cytology Source Type: research
Authors: Çevirme D, Adademir T, Kafalı Başaran E, Şavluk ÖF, Elibol A, Erkanlı Şentürk G, Akkaya H, Yılmaz B Abstract Background/aim: Alprostadil and iloprost are successful agents used for both pulmonary hypertension and extremity ischemia treatment. Different systemic effects of these agents may change the preferences of clinical usage. Superiority of preventing ischemia/ reperfusion (IR) injury is a criterion for clinical preference of these agents. The present study was designed to compare the protective effects of alprostadil and iloprost in a rat model of IR injury. Materials and method...
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Conclusion: Although further studies with larger numbers of patients are required, this study demonstrated that the expression levels of miR-200b-3p and miR-378a-5p decrease in MODY3 patients and suggests that miR-200b-3p is an especially strong candidate to use clinically for selecting suspected MODY3 patients. PMID: 29916222 [PubMed]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Conclusion: Serum vasohibin-1 and sST2 levels were not associated with decline in renal function. Elevated serum vasohibin levels may be a compensatory response to proteinuria in patients with predialysis CKD. The measurement of serum sST2 levels might contribute to early detection of hypertension in patients. PMID: 29914255 [PubMed]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Conclusion: Cardiometabolic risk factors as well as the visfatin levels were established to be higher in patients with adrenal adenoma. Elevated visfatin levels might play a role in the development and metabolic process of adrenal adenoma. PMID: 29914251 [PubMed]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Conclusion: It is concluded that adopting a palliative care approach eases symptom management. While this approach decreases the burden of symptoms, it at the same time increases the quality of life of DPs and their families. PMID: 29914249 [PubMed]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Preterm birth continues to be an important and global obstetrical problem. An estimated 15 million preterm births occur throughout the world annually, resulting in approximately 1 million deaths.1 In addition to the high mortality rate, preterm birth is associated with short- and long-term adverse effects.2 –6 During their early years, infants born prematurely have high rates of cerebral palsy, sensory deficits, learning disabilities, and respiratory illnesses.7–9 Later in life, these individuals have an increased incidence of diabetes, hypertension, metabolic syndrome, and other adult chronic dise ases.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Editorial Source Type: research
Artificial intelligence continues to prove valuable across many healthcare specialties, but diabetes management really seems to stand out as an area where AI can truly make a direct impact on patient lives. The latest example of the industry embracing AI's capabilities for the millions of people living with diabetes is an app co-developed by Medtronic and IBM Watson Health dubbed the Sugar.IQ smart diabetes assistant. The app is designed to simplify and improve daily diabetes management by leveraging AI and analytic technologies from IBM Watson Health to continually analyze how an individual's glucose level responds to the...
Source: MDDI - Category: Medical Devices Authors: Tags: Digital Health Source Type: news
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