Cellphone-based microscope leads to possible strategy for treating river blindness
More than 16,000 volunteers provided finger-prick blood samples for the study.
[Thomson Reuters Foundation] There were lots of people suffering, needing help, but there was also fear. People were slow to trust.
ConclusionThe culture system we have established forO.volvulus young adult worms offers a promising new platform to advance drug discovery against the human filarial parasite,O.volvulus and thus supports the continuous pursuit for effective macrofilaricidal drugs. However, thisin vitro culturing system will have to be further validated for reproducibility before it can be rolled out as a drug screen for decision making in macrofilaricide drug development programs.
by Chelsea Fischer, Iosune Ibiricu Urriza, Christina A. Bulman, KC Lim, Jiri Gut, Sophie Lachau-Durand, Marc Engelen, Ludo Quirynen, Fetene Tekle, Benny Baeten, Brenda Beerntsen, Sara Lustigman, Judy Sakanari River blindness and lymphatic filariasis are two filarial diseases that globally affect millions of people mostly in impoverished countries. Current mass drug administration programs rely on drugs that primarily target the microfilariae, which are released from adult female worms. The female worms can live for several years, releasing millions of microfilariae throughout the course of infection. Thus, to stop transmi...
Onchocerciasis, or river blindness, is a dermal filariasis caused by infection with the nematode parasite Onchocerca volvulus, transmitted to humans through the bites of blackflies of the genus Simulium. Despite ...
by Piero L. Olliaro, Annette C. Kuesel, Christine M. Halleux, Mark Sullivan, John C. Reeder
The new data could help identify treatments for diseases ranging from river blindness to schistosomiasis.
In this study, we developed and validated a LC-MS/MS method of MOX in human, monkey and mouse plasma. The separation was achieved on an ACE C18 (50 × 50 mm, 3μ) column with isocratic elution using 0.1% acetic acid and methanol:acetonitrile (1:1, v/v) as mobile phase. MOX was quantitated using MS/MS with electrospray ionization source operating in negative MRM mode. The MRM precursor ion → product ion transitions for MOX and abamectin (IS) were m/z 638.40→236.30 and m/z 871.50→565.35 respectively. The MS/MS response was linear over the concentration range from 0.1-1000 ng/mL in plasma with a correlat...
ConclusionKeen observation on the part of physicians is mandatory during the administration of ivermectin for quick recognition and prevention of this adverse drug reaction.
(Scripps Research Institute) Scientists at Scripps Research have developed a urine diagnostic to detect the parasitic worms that cause river blindness, also called onchocerciasis, a tropical disease that afflicts 18 to 120 million people worldwide.
[East African] Uganda is edging closer to eliminating onchocerciasis or river blindness, a disease that can lead to permanent blindness if left untreated, but more effort from South Sudan and the Democratic Republic of Congo will be crucial in preventing cross-border transmission.