Salvage therapy with topical posaconazole in lung transplant recipients with invasive scedosporium infection

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Source: American Journal of Transplantation - Category: Transplant Surgery Authors: Tags: Case Report Source Type: research

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Background: Chronic respiratory diseases contribute to the development of anxiety and depression. In bronchiectasis (BE), it is unclear whether these comorbidities are related to general or disease-related quality of life (HRQoL) or symptoms.Aims: To evaluate the correlation between anxiety and depression and QoL in patients with BE.Methods: 26 subjects with non-cystic fibrosis BE of both sexes, 56±16 years, classified by the Bronchiectasis Severity Index (BSI), answered to the Mini Mental State Examination (MMSE), Anxiety and Depression Scale (HADS), Medical Outcomes Study 36 – Item Short – Form Health ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Physiotherapists Source Type: research
Chronic rhinosinusitis (CRS) and nasal polyposis are common comorbidities among Cystic Fibrosis (CF) patients. These conditions are managed with education to routine nasal irrigations, periodical follow-ups that consists of quality of life questionnaires, annual nasal fibroscopy and nasal lavage fluid analysis.Aim: To retrospectively analyze CF patients with symptoms of chronic rhinosinusitis and nasal polyposis.An observational retrospective analysis was performed from 2017 to 2018 among clinically stable adult CF patients. Respiratory function indices, anthropometric data, routine airway clearance techniques and Sino-nas...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Physiotherapists Source Type: research
Aim: To investigate the role of different types of bronchial infection and respiratory symptoms upon lung function decline.Methods: 89 children and adults with CF (mean (SD) age: 11.71 (6) years) performed 1340 serial Multiple Breath Washout (MBW) tests and 980 spirometries over a 5-year period. Respiratory symptoms (cough, sputum, nasal congestion) and Pulmonary Exacerbations (PEx) were recorded. Pseudomonas Aeruginosa, Staphylococcus aureus infection, as well as aspergillus, candida, Achromobacter, Acinetobacter, Serratia and Stenotrophomonas Maltophilia isolated from cough swabs/ sputum cultures were recorded.Results: M...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Cystic fibrosis Source Type: research
Conclusions: this is the largest study in pediatric NCFB. As the management of NCFB affected patients remains problematic, a better definition of clinical, radiological and microbiological features of NCFB is required to improve their management.Reference:1. BMC Pediatrics 2014;14: 299
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Paediatric bronchology Source Type: research
Introduction: Patients with neuromuscular diseases (NMD) frequently have respiratory complications including secretion retention related to weak cough, aspiration syndromes, and chest wall deformity. Nebulised hypertonic saline (HTS) is useful in cystic fibrosis to remove secretions and decrease exacerbations. We know of no data on use in NMD.Hypothesis: Nebulised HTS in NMD decreases respiratory complications and is acceptable to patients.Aims: To assess whether treatment with nebulised HTS in NMD 1) decreases respiratory exacerbations, 2) improves ease of airway clearance, and 3) explore the participants’ perceptio...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Rehabilitation and chronic care Source Type: research
In conclusion, the incidence of M abscessus does not seem to be increasing in non-CF patients in our institution. There may be an epidemiological link with acid suppression and reflux disease, this hypothesis has been previously reported in patients with CF.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory infections Source Type: research
AbstractPurposeAustralian data regarding the management of patients with bronchiectasis is scarce. We sought to compare the management of adults with bronchiectasis attending tertiary Australian centres with recent national and international guidelines.MethodsThe Australian Bronchiectasis Registry is a centralised database of patients with radiologically confirmed bronchiectasis unrelated to cystic fibrosis recruited from 14 tertiary Australian hospitals. We excluded children (
Source: Lung - Category: Respiratory Medicine Source Type: research
Pediatric non-cystic fibrosis (CF) bronchiectasis is characterized by endobronchial suppuration, airway neutrophilic inflammation and poor mucus clearance and is associated with persistent productive cough due to recurrent airway infections. Most recommendations are based on expert opinion or extrapolated from CF practice. The present narrative review aims to address some issues on the management of children or adolescents with non CF-bronchiectasis that still require attention, and analyze what available literature offers to reply to open questions.
Source: Pediatrics and Neonatology - Category: Perinatology & Neonatology Authors: Tags: Review Article Source Type: research
Abstract Purinergic signaling was proposed in 1972, after it was demonstrated that adenosine 5'-triphosphate (ATP) was a transmitter in nonadrenergic, noncholinergic inhibitory nerves supplying the guinea-pig taenia coli. Later, ATP was identified as an excitatory cotransmitter in sympathetic and parasympathetic nerves, and it is now apparent that ATP acts as a cotransmitter in most, if not all, nerves in both the peripheral nervous system and central nervous system (CNS). ATP acts as a short-term signaling molecule in neurotransmission, neuromodulation, and neurosecretion. It also has potent, long-term (trophic) ...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
Smoke-measuring smart shirts, breath sound analyzing algorithms, and smart inhalers pave the way of pulmonology and respiratory care into the future. As the number of patients suffering from asthma, COPD, or lung cancer due to rising air pollution and steady smoker-levels will unfortunately not decrease any time soon, we looked around what technology can do to help both patients and caregivers. The results are breathtaking. Attacks of breathlessness are too common The diseases which pulmonologists and respiratory care specialists attempt to fight are among the most common conditions in the modern world – and t...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Artificial Intelligence Future of Medicine Health Sensors & Trackers AI asthma cancer cancer treatment care COPD diagnostics inhaler lung lung cancer management medical specialty pulmonology respiratory respiratory care Source Type: blogs
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