Genetically modified skin grown from stem cells saved a 7-year-old boy ’ s life

Scientists reported Wednesday that they genetically modified stem cells to grow skin that they successfully grafted over nearly all of a child's body — a remarkable achievement that could revolutionize treatment of burn victims and people with skin diseases. The research, published in the journal Nature, involved a 7-year-old  boy who suffers from a genetic disease known as junctional epidermolysis […]Related:She signed up to be a surrogate mother — and unwittingly gave away her own childWhite House opioid commission calls for wide-ranging changes to anti-drug policiesScreams, torture and so much blood: The gruesome world of 19th-century surgery
Source: Washington Post: To Your Health - Category: Consumer Health News Source Type: news

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Planta Med DOI: 10.1055/a-0850-0224With central European approval in January 2016 for a betulin-oleogel (Episalvan), used to accelerate wound closure in partial thickness wounds, the herbal active ingredient triterpene dry extract (betulin), from birch bark, was introduced into therapy for the first time. Clinical evidence of accelerated wound healing was provided in a new study design by means of intraindividual comparison of split-thickness skin graft donor wounds and burn wounds. Clinical results of a phase II study evidencing accelerated wound healing in the rare disease epidermolysis bullosa are also available, and a ...
Source: Planta Medica - Category: Drugs & Pharmacology Authors: Tags: Reviews Source Type: research
It remains a challenge to preserve stem and progenitor cells during expansion of epidermal keratinocytes ex vivo under serum-free and feeder-cell-free culture condition. This limitation greatly hinders the development of advanced autologous cell and gene therapeutics for inherited skin diseases such as epidermolysis bullosa and injuries such as severe burns. We have developed a serum-free and feeder-cell-free culture technology (EpiX ™) that allows rapid generation of more than one-trillion epidermal keratinocytes while retaining the stem and progenitor cell population.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Tissue Regeneration and Wound Healing Source Type: research
Photo by Alison Bents Photography for Tamarack Habilitation Technologies, Inc. A company that makes ultra-low-friction fabric for people with burn injuries, amputations and pressure sores has launched a clothing line for children with a painful skin condition. Known as “butterfly children,” these patients have epidermolysis bullosa (EB), a rare genetic disorder in which their bodies do not produce a protein that would enable the skin to adhere to itself. Their extremely fragile skin blisters and tears from minor friction or trauma, making it seem as fragile as the wings of a butterfly. When officials with low-f...
Source: Mass Device - Category: Medical Devices Authors: Tags: Blog Pediatrics Wound Care Tamarack Habilitation Technologies Inc. University of Minnesota Source Type: news
CONCLUSION: this small case series suggests that the use of the Allevyn Gentle Border Lite dressing range can positively impact the clinical, patient and health economic outcomes of paediatric EB patients. PMID: 29944424 [PubMed - in process]
Source: British Journal of Nursing - Category: Nursing Authors: Tags: Br J Nurs Source Type: research
Nowadays there are several diseases leading to partial or total atrophy of the hands, such as Epidermolysis Bullosa (EB), arthritis, osteoarthritis, burns or hand amputations. Patients from these diseases are affected to perform their daily activities which include eating, writing, brushing his teeth or drawing. Overall, these patients have their autonomy highly compromised. Current solutions for people with atrophied hands are very basic, mainly because the avalible options are prosthesis for people who lack a whole hand from the wrist up.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Pathophysiology and Therapeutics Source Type: research
CONCLUSION: Delayed islanded reverse sural artery perforator flap is a reliable and versatile option for resurfacing soft tissue defects of lower limb proximal to the toes with lesser complications and extended coverage area. PMID: 29394972 [PubMed - in process]
Source: Hand Surgery - Category: Surgery Authors: Tags: J Coll Physicians Surg Pak Source Type: research
(Ruhr-University Bochum) A medical team at the Ruhr-Universit ä t Bochum's burn unit and the Center for Regenerative Medicine at the University of Modena (Italy) were the first ever to successfully treat a child suffering from extensive skin damage using transplants derived from genetically modified stem cells. The boy is a so-called butterfly child: he suffers from epidermolysis bullosa, a genetic skin disease that had destroyed approximately 80 percent of his epidermis.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
No abstract available
Source: Journal of Burn Care and Research - Category: Rehabilitation Tags: Letters to the Editor Source Type: research
Following cutaneous injury in adult mammals, one of two outcomes can occur: successful healing with scar formation or nonsuccessful healing and a chronic wound. In humans, scar formation can be classified in terms of “normal scar” formation versus pathologically increased fibrosis, as seen in hypertrophic scarring and keloids (1). Although scarring does not look or function like surrounding unwounded skin, it allows one to survive injury (and hence, procreate). However, extensive scarring from burns and conditions such as scleroderma or epidermolysis bulosa are not only unsightly but also contribute to substant...
Source: ScienceNOW - Category: Science Authors: Tags: Tissue Regeneration Source Type: news
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Source: Journal of the European Academy of Dermatology and Venereology - Category: Dermatology Authors: Tags: Review Article Source Type: research
More News: Burns | Children | Epidermolysis Bullosa | Genetics | Health | Skin | Skin Graft | Stem Cell Therapy | Stem Cells