Genetically modified skin grown from stem cells saved a 7-year-old boy ’ s life
Scientists reported Wednesday that they genetically modified stem cells to grow skin that they successfully grafted over nearly all of a child's body — a remarkable achievement that could revolutionize treatment of burn victims and people with skin diseases. The research, published in the journal Nature, involved a 7-year-old boy who suffers from a genetic disease known as junctional epidermolysis […]Related:She signed up to be a surrogate mother — and unwittingly gave away her own childWhite House opioid commission calls for wide-ranging changes to anti-drug policiesScreams, torture and so much blood: The gruesome world of 19th-century surgery
Planta Med DOI: 10.1055/a-0850-0224With central European approval in January 2016 for a betulin-oleogel (Episalvan), used to accelerate wound closure in partial thickness wounds, the herbal active ingredient triterpene dry extract (betulin), from birch bark, was introduced into therapy for the first time. Clinical evidence of accelerated wound healing was provided in a new study design by means of intraindividual comparison of split-thickness skin graft donor wounds and burn wounds. Clinical results of a phase II study evidencing accelerated wound healing in the rare disease epidermolysis bullosa are also available, and a ...
It remains a challenge to preserve stem and progenitor cells during expansion of epidermal keratinocytes ex vivo under serum-free and feeder-cell-free culture condition. This limitation greatly hinders the development of advanced autologous cell and gene therapeutics for inherited skin diseases such as epidermolysis bullosa and injuries such as severe burns. We have developed a serum-free and feeder-cell-free culture technology (EpiX ™) that allows rapid generation of more than one-trillion epidermal keratinocytes while retaining the stem and progenitor cell population.
Photo by Alison Bents Photography for Tamarack Habilitation Technologies, Inc. A company that makes ultra-low-friction fabric for people with burn injuries, amputations and pressure sores has launched a clothing line for children with a painful skin condition. Known as “butterfly children,” these patients have epidermolysis bullosa (EB), a rare genetic disorder in which their bodies do not produce a protein that would enable the skin to adhere to itself. Their extremely fragile skin blisters and tears from minor friction or trauma, making it seem as fragile as the wings of a butterfly. When officials with low-f...
CONCLUSION: this small case series suggests that the use of the Allevyn Gentle Border Lite dressing range can positively impact the clinical, patient and health economic outcomes of paediatric EB patients. PMID: 29944424 [PubMed - in process]
Nowadays there are several diseases leading to partial or total atrophy of the hands, such as Epidermolysis Bullosa (EB), arthritis, osteoarthritis, burns or hand amputations. Patients from these diseases are affected to perform their daily activities which include eating, writing, brushing his teeth or drawing. Overall, these patients have their autonomy highly compromised. Current solutions for people with atrophied hands are very basic, mainly because the avalible options are prosthesis for people who lack a whole hand from the wrist up.
CONCLUSION: Delayed islanded reverse sural artery perforator flap is a reliable and versatile option for resurfacing soft tissue defects of lower limb proximal to the toes with lesser complications and extended coverage area. PMID: 29394972 [PubMed - in process]
(Ruhr-University Bochum) A medical team at the Ruhr-Universit ä t Bochum's burn unit and the Center for Regenerative Medicine at the University of Modena (Italy) were the first ever to successfully treat a child suffering from extensive skin damage using transplants derived from genetically modified stem cells. The boy is a so-called butterfly child: he suffers from epidermolysis bullosa, a genetic skin disease that had destroyed approximately 80 percent of his epidermis.
No abstract available
Following cutaneous injury in adult mammals, one of two outcomes can occur: successful healing with scar formation or nonsuccessful healing and a chronic wound. In humans, scar formation can be classified in terms of “normal scar” formation versus pathologically increased fibrosis, as seen in hypertrophic scarring and keloids (1). Although scarring does not look or function like surrounding unwounded skin, it allows one to survive injury (and hence, procreate). However, extensive scarring from burns and conditions such as scleroderma or epidermolysis bulosa are not only unsightly but also contribute to substant...
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