Penn Medicine launches first clinical trial for uterine transplant in the northeast

(University of Pennsylvania School of Medicine) Penn Medicine will conduct the Northeast's first clinical trial of uterine transplants, to provide women with Uterine Factor Infertility (UFI) -- an irreversible form of female infertility that affects as many as 5 percent of women worldwide and 50,000 women in the United States -- with a new path to parenthood.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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There is rapidly growing interest in uterine transplantation for the management of uterine factor infertility (UFI). Recent experimental procedures have demonstrated that women with congenital or acquired absence of a uterus can become pregnant and give birth to a child after a successful uterine transplant, with the first birth occurring in 2015 [1]. The procedure was once considered only in theory, remaining a unique intersection of reproductive and transplant medicine that had never been undertaken.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Editorial Source Type: research
Authors: Padela AI, Clayville K PMID: 30040553 [PubMed - in process]
Source: American Journal of Bioethics - Category: Medical Ethics Tags: Am J Bioeth Source Type: research
Authors: Bruno B, Arora KS Abstract Research teams have made considerable progress in treating absolute uterine factor infertility through uterus transplantation, though studies have differed on the choice of either deceased or living donors. While researchers continue to analyze the medical feasibility of both approaches, little attention has been paid to the ethics of using deceased versus living donors as well as the protections that must be in place for each. Both types of uterus donation also pose unique regulatory challenges, including how to allocate donated organs; whether the donor / donor's family has any...
Source: American Journal of Bioethics - Category: Medical Ethics Tags: Am J Bioeth Source Type: research
Conditions:   Mrk Anomaly;   Infertility, Female Intervention:   Procedure: uterus transplantation surgery and IVF Sponsors:   Sahlgrenska University Hospital, Sweden;   Saint Joseph University, at Bellevue Medical Centre Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsEvidence does not yet support clinical application of SSCs in humans. However, significant progress in the in vitro and in vivo development of SSCs, including differentiation into functional germ cells, gives reason for cautious optimism for future research.
Source: Arab Journal of Urology - Category: Urology & Nephrology Source Type: research
Conditions:   Absolute Uterine Factor Infertility;   Transplantation;   Mrk Anomaly Intervention:   Procedure: uterus transplantation Sponsor:   Sahlgrenska University Hospital, Sweden Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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