Penn Medicine launches first clinical trial for uterine transplant in the northeast

(University of Pennsylvania School of Medicine) Penn Medicine will conduct the Northeast's first clinical trial of uterine transplants, to provide women with Uterine Factor Infertility (UFI) -- an irreversible form of female infertility that affects as many as 5 percent of women worldwide and 50,000 women in the United States -- with a new path to parenthood.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Conclusions In conclusion, articles in this Research Topic made a very significant contribution to our understanding of the role played by environmental factors, dysbiotic conditions, and infections in triggering diseases. Since this is a rapidly expanding area of research, many other factors contributing to the onset of these diseases are not covered here. We are confident, however, that further studies will expand the list as well as bring a better understanding of mechanisms involved in the onset of autoimmune and autoinflammatory diseases. Author Contributions All authors listed have made a substantial, direct and i...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conservation of chicken male germ line by orthotopic transplantation of primordial germ cells from genetically distant donors†. Biol Reprod. 2019 Apr 13;: Authors: Mucksová J, Reinišová M, Kalina J, Lejčková B, Hejnar J, Trefil P Abstract Successful derivation and cultivation of primordial germ cells (PGC) opened the way to efficient transgenesis and genome editing in the chicken. Furthermore, implantation of male PGCs from non-chicken galliform species into the chicken embryos resulted in cross-species germ line chimeras and viable offspring. We have recently impro...
Source: Biology of Reproduction - Category: Reproduction Medicine Authors: Tags: Biol Reprod Source Type: research
ConclusionsWe developed a novelex vivo sheep uterus model for prolonged perfusion. This model proved to be able to distinguish reperfusion injury ‐related differences associated to organ preservation. The experimental setup is a platform that can be used to conduct further studies on uterine ischemia‐ and reperfusion injury that may lead to improved human uterus transplantation protocols.This article is protected by copyright. All rights reserved.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: Original Research Article Source Type: research
There is nothing more frustrating than when the cure is part of the problem. Because depression is prevalent in patients with physical disorders like cancer, stroke, and heart disease, medications often interact with each other, complicating treatment. To appropriately manage depression, you and your physician need to evaluate all medications involved and make sure they aren’t cancelling each other out. A review in the journal Dialogues in Clinical Neuroscience a while back highlighted certain medications that can cause depression. The following are medications to watch out for. Medications to Treat Seizures and Park...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Depression Medications Drug Interactions Mood Disorder Source Type: blogs
Sperm production is one of the most complex biological processes in the body. In vitro production of sperm is one of the most important goals of researches in the field of male infertility treatment, which is ...
Source: Biological Research - Category: Biomedical Science Authors: Tags: Research article Source Type: research
Baby monkey is first primate created using sperm from tissue transplanted into dad, Published online: 21 March 2019; doi:10.1038/d41586-019-00938-9The technique could help boys made infertile by cancer treatment to become fathers later in life.
Source: Nature AOP - Category: Research Authors: Source Type: research
Uterine transplant is by nature a surgically innovative procedure, therefore it is not surprising that innovations within this field are progressing rapidly and in novel directions. Once regarded as an incurable diagnosis, studies show that absolute uterine factor infertility is now considered amenable to surgical correction via transplantation. From the initial series of live births in Sweden (1) to more recently reported deliveries in the United States, Brazil, China, and India, the accumulation of successful pregnancies is the strongest evidence of the procedure's potential application as a clinical tool for women with ...
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: EDITORIAL Source Type: research
CONCLUSIONS: The ways in which women with AUFI conceptualize this condition in their lives and choices around UTx and participating in a study of the procedure are multifaceted and textured. These perspectives are critical to understanding its ethical, legal, and social implications. PMID: 30855220 [PubMed - as supplied by publisher]
Source: AJOB Primary Research - Category: Medical Ethics Tags: AJOB Empir Bioeth Source Type: research
(Abstracted from Science 2018;362:356–360) Studies have shown that mouse pluripotent stem cells (PSCs) can be induced into primordial germ cell–like cells (hPGCLCs), which, following transplantation under appropriate conditions, can contribute to the development of gametes capable of developing into fertile offspring. Human in vitro gametogenesis from PSCs has long-reaching implications in reproductive medicine but has not yet been achieved.
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: GYNECOLOGY: INFERTILITY/REPRODUCTIVE TECHNOLOGIES Source Type: research
(Abstracted from Hum Reprod 2018;33:2249–2255) Cytotoxic cancer treatments, including chemotherapy and radiotherapy, cause damage to spermatogenic stem cells (SSCs), jeopardizing the fertility of young men of reproductive age. One potential method for future production of sperm in this population is SSC transplantation.
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: GYNECOLOGY: INFERTILITY/REPRODUCTIVE TECHNOLOGIES Source Type: research
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