First case of echinocandin resistance caused by fks1 mutation found in Aspergillus

First case of echinocandin resistance caused by fks1 mutation found in AspergillusTue, 11/07/2017 - 15:10News blog
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news

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In this study, a rotating nonthermal plasma (NTP) reactor was designed and its practical use for the inactivation of microorganisms on dried granular agricultural products such as black pepper was investigated. As the target microorganism to inactivate in the rotating NTP reactor, Aspergillus spores were artificially inoculated on whole black peppers. Inactivation treatments were carried out under several conditions. Rotating the NTP reactor facilitated the inactivation of the Aspergillus spores on the whole black peppers, and a decrease in the survival ratio of three orders (3 Log) was achieved after 4 min treatment. Usin...
Source: Food Control - Category: Food Science Source Type: research
Omics data provide deep insights into overall biological processes of organisms. However, integration of data from different molecular levels such as transcriptomics and proteomics, still remains challenging. ...
Source: BMC Systems Biology - Category: Molecular Biology Authors: Tags: Research article Source Type: research
Letters in Applied Microbiology, EarlyView.
Source: Letters in Applied Microbiology - Category: Microbiology Authors: Source Type: research
Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.8b05599
Source: Journal of Agricultural and Food Chemistry - Category: Food Science Authors: Source Type: research
This study found that inactivation of GcnE activated the production of secondary metabolites in A. niger. The biosynthetic pathway for nigerpyrone and its derivatives was identified and characterized via gene knockout and complementation experiments. A biosynthetic model of this group of pyran-based fungal metabolites was proposed.
Source: Microbiological Research - Category: Infectious Diseases Source Type: research
Publication date: 15 March 2019Source: Food Chemistry, Volume 276Author(s): Junya Kamijo, Kiyota Sakai, Hiromitsu Suzuki, Kengo Suzuki, Emi Kunitake, Motoyuki Shimizu, Masashi KatoAbstractPectinolytic enzymes are used in diverse industrial applications. We sought to isolate a pectate lyase from Aspergillus luchuensis var. saitoi, a filamentous fungus used in traditional food and beverage preparation in Japan. The identified enzyme, named AsPelA, is orthologous to PelA from A. luchuensis mut. kawachii (AkPelA); the enzymes exhibit 99% amino acid sequence identity, with Ile140 and Val197 of AsPelA being replaced by Val and A...
Source: Food Chemistry - Category: Food Science Source Type: research
Organic LettersDOI: 10.1021/acs.orglett.8b02942
Source: Organic Letters - Category: Chemistry Authors: Source Type: research
The Journal of Organic ChemistryDOI: 10.1021/acs.joc.8b01142
Source: The Journal of Organic Chemistry - Category: Chemistry Authors: Source Type: research
In this study, Desmonostoc muscorum CCALA125 strain extracts were enriched by polymeric resin treatment, and subjected to HPCCC affording three cyclic lipopeptides (1–3), which were further repurified by semi-preparative HPLC, affording 1, 2, and 3, with a purity of 86%, 92%, and 90%, respectively. The chemical identities of 2–3 were determined as muscotoxins A and B, respectively, by comparison with previously reported ESI-HRMS/MS data, whereas 1 was determined as a novel muscotoxin variant (muscotoxin C) using NMR and ESI-HRMS/MS data. Owing to the high yield (50 mg), compound 2 was broadly screened f...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
vid Grande-Tovar Several biomaterials, including natural polymers, are used to increase cellular interactions as an effective way to treat bone injuries. Chitosan (CS) is one of the most studied biocompatible natural polymers. Graphene oxide (GO) is a carbon-based nanomaterial capable of imparting desired properties to the scaffolds. In the present study, CS and GO were used for scaffold preparation. CS was extracted from the mycelium of the fungus Aspergillus niger. On the other hand, GO was synthesized using an improved Hummers-Offemann method and was characterized by Fourier transform infrared spectroscopy (FTIR), R...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
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