Addressing Unmet Needs in Persons with Dementia to Decrease Behavioral Symptoms and Improve Quality of Life (R01 Clinical Trial Optional)
Funding Opportunity PA-18-147 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA) is to stimulate clinical research addressing behavioral and psychological symptoms of dementia (BPSD) and the association of BPSD with unmet physical, social, or environmental needs in persons with dementia.
ConclusionsThese results suggest that TENS application can be used for functional maintenance of patients with dementia. Further research is needed to underpin these preliminary results.
DEMENTIA is not a disease in and of itself. Rather it is a collection of symptoms brought on by brain damage. Watch out for this change in behaviour - it may indicate the onset.
For this edition of Annals, focusing on Drug Allergy, From Pages of Allergy Watch highlights reviews of articles that concentrate on reactions to medications. The initial report investigates the impact of PPI and antibiotics that can impact the microbiome on the development of allergy in children. The next review raises the concern about risk for dementia with H1 antihistamines. The potential risk for complications of infections in patients with penicillin allergy is reviewed in the next article.
There are a number of things that can increase the risk of dementia: age, of course, as well as certain genetic profiles and behaviors such as smoking and drinking. Some of the same things that contribute to heart disease, such as high cholesterol levels and the build up of plaques in the blood vessels, can also boost the chances of developing dementia. And in a large study published in JAMA Internal Medicine conducted in the UK, researchers report another possible factor: a group of drugs known as anticholinergics. These include prescription medications for treating depression, pulmonary disease, and Parkinson’s, as...
This report seeks to highlight the human impact that this has on people living with dementia. It focuses on themes of equality, non-discrimination, participation and inclusion.
Publication date: Available online 25 June 2019Source: NeuroImageAuthor(s): Ying Yu, Lin-Feng Yan, Qian Sun, Bo Hu, Jin Zhang, Yang Yang, Yu-Jie Dai, Wu-Xun Cui, Si-Jie Xiu, Yu-Chuan Hu, Chun-Ni Heng, Qing-Quan Liu, Jun-Feng Hou, Yu-Yun Pan, Liang-Hao Zhai, Teng-Hui Han, Guang-Bin Cui, Wen WangAbstractType 2 diabetes mellitus (T2DM) is a significant risk factor for mild cognitive impairment (MCI) and the acceleration of MCI to dementia. The high glucose level induce disturbance of neurovascular (NV) coupling is suggested to be one potential mechanism, however, the neuroimaging evidence is still lacking. To assess the NV de...
Conclusion: Smell identification deficit in AD/MCI is strongly associated with the memory domain of cognitive function and with atrophy of the medial temporal lobe.Eur Neurol
According to a working paper from the Organisation for Economic Co-operation and Development (OECD), France, Germany, and the Netherlands are among the many European countries that have experienced a slowdown in life expectancy gains since 2011. In the United States and the United Kingdom, some mortality gains have even reversed, in part because of increasing death from accidental drug poisonings. The OECD also reported that diseases of old age, including dementia and respiratory illnesses like pneumonia and influenza, are major contributors to the slowdown.
We describe a case of a patient treated for cognitive dysfunction (CD) with suspected thiamine deficiency (TD). A 74-year-old man with gastric cancer presented with grade 3 diarrhea and grade 1 anorexia. He had been receiving trastuzumab plus tegafur (a chemotherapeutic fluorouracil prodrug), gimeracil, and oteracil (S-1) and oxaliplatin. On admission, cognitive function was assessed with the Hasegawa's Dementia Scale (HDS-R) because he had impaired short-term memory. His thiamine levels increased from 22 to 109 ng/mL after administration of 75 mg of thiamine. Furthermore, the patient's HDS-R score improved from 9 to 22, a...
Here ’s what research suggests about a class of drugs called anticholinergics, which treat a wide range of ailments, from depression to bladder issues.