MicroRNA-155 regulates the proliferation, cell cycle, apoptosis and migration of colon cancer cells and targets CBL.
MicroRNA-155 regulates the proliferation, cell cycle, apoptosis and migration of colon cancer cells and targets CBL.
Exp Ther Med. 2017 Nov;14(5):4053-4060
Authors: Yu H, Xu W, Gong F, Chi B, Chen J, Zhou L
Abstract
MicroRNA-155 (miR-155) is a well-studied miR and acts as an oncomiR in numerous cancer types. However, the biological functions of miR-155 in colon cancer as well as its target genes have remained to be fully elucidated. In order to investigate the biological functions of miR-155, MTT, colony formation and wound healing assays, cell cycle analysis and detection of apoptosis were performed. The results demonstrated that miR-155 promoted the proliferation of colon cancer cells and enhanced their colony formation capacity, promoted their cell cycle progression and inhibited apoptosis. miR-155 also promoted the migration of colon cancer cells. In the present study, casitas B-lineage lymphoma was identified as a novel target of miR-155. The present study suggested that miR-155 functions as an oncomiR in colon cancer cells and may become a promising therapeutic target for colon cancer therapy.
PMID: 29104623 [PubMed]
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
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