(-)-P7C3-S243 protects a rat model of Alzheimer ’s disease from neuropsychiatric deficits and neurodegeneration without altering amyloid deposition or reactive glia

In addition to cognitive deficits, Alzheimer ’s disease (AD) is also associated with other neuropsychiatric symptoms, including severe depression. Indeed, depression often precedes cognitive deficits in patients with AD. Unfortunately, the field has seen only minimal therapeutic advances, underscoring the critical need for new treatments. P7 C3 aminopropyl carbazoles promote neuronal survival by enhancing nicotinamide adenine dinucleotide flux in injured neurons. Neuroprotection with P7C3 compounds has been demonstrated in preclinical models of neurodegeneration by virtue of promoting neuronal survival independently of early disease-spe cific pathology, resulting in protection from cognitive deficits and depressive-like behavior.

Source: Biological Psychiatry - November 6, 2017 Category: Psychiatry Authors: Jaymie R. Voorhees, Matthew T. Remy, Coral J. Cintr ón-Pérez, Eli El Rassi, Michael Z. Kahn, Laura M. Dutca, Terry C. Yin, Latisha M. McDaniel, Noelle S. Williams, Daniel J. Brat, Andrew A. Pieper Tags: Archival Report Source Type: research