Vitamin D deficiency and aspergillosis
Vitamin D deficiency and aspergillosisMon, 11/06/2017 - 17:31News blog
Condition: Vitamin D Deficiency Intervention: Sponsor: Yonsei University Completed
Condition: Invasive Aspergillosis in Patients With Onco-haematological Diseases Intervention: Diagnostic Test: DNA extraction and detection of Aspergillus fumigatus in serum samples Sponsors: Assistance Publique - Hôpitaux de Paris; Société ADEMTECH SA Not yet recruiting
Multiple pulmonary metastases with halo-sign from malignant mixed Müllerian tumors. Oncol Lett. 2017 Dec;14(6):6645-6649 Authors: Tian HW, Yang WB, Yang MJ, Liu JY, Zhang JC, Tao XN, Zhou Q Abstract The lungs are one of the most common organs to which cancer metastasizes, but are a location not common for uterine sarcoma. A malignant mixed Müllerian tumor (MMMT) of the uterus is an extremely rare and aggressive sarcoma, characterized by a mixture of epithelial and mesenchymal components. There are few reports regarding the pulmonary metastasis from MMMTs. The present study presents the case o...
Conclusion: The IFI incidence and mortality rate were similar to that reported in the literature. The IFI rate was higher in the group using prophylaxis, as this is a high-risk group. Although the IFI rate was not significantly different between groups using prophylaxis, patients should be followed closely for the effective use of posaconazole prophylaxis. PMID: 29151329 [PubMed]
Wed, 11/22/2017 - 11:23News blog
In conclusion, a dysbiotic mycobiome dominated by C. albicans was found in association with OSCC, a finding worth further investigation. PMID: 29152157 [PubMed]
Summary Recent years have seen important advances in the diagnosis of invasive pulmonary aspergillosis (IPA), complemented by the introduction of new therapies. Despite this, IPA remains a major cause of infection‐related mortality in patients with haematological diseases. There are two main reasons for this. First, diagnosis of IPA remains a challenge, since risk factors and the clinical, radiological and mycological presentations vary not only by fungal disease stage, but also by patient group (eg neutropenic vs non‐neutropenic patients). Diagnosis is particularly challenging in patients receiving mould‐active prop...
Summary Fungal sensitisation in adults is associated with severe asthma but prevalence and clinical significance of fungal sensitisation remains unclear in paediatric population. The aim of this study was to study the association of fungal sensitisation with disease severity in children with persistent asthma. One hundred children with persistent asthma in age group 7‐15 years, symptom duration>2 years and forced expiratory volume in first second>50% of expected were enrolled. Skin prick test (SPT) to 8 fungal antigens and total serum immunoglobulin E (IgE) were done. Fungal sensitisation was described as...
Conclusion and Clinical RelevanceEosinophils are phenotypically and functionally heterogeneous. As shown here, eosinophils from fungal allergen–challenged wild‐type mice maintain a distinct cytokine profile, and, unlike eosinophils isolated from IL5tg mice, they survive ex vivo in the absence of exogenous pro‐survival cytokine support. As treatments for asthma currently in development focus on limiting eosinophil viability via strategic cytokine blockade, the molecular mechanisms underlying differential survival merit further investigation.
Methyl (3-hydroxy-4-(2-hydroxy-6-methylheptan-2-yl)benzoyl)glycinate (1), a new sydonic acid derivative with glycinate, together with sydonic acid (2), sydowic acid (3), and 7-deoxy-7,14-didehydrosydonic acid (4), were isolated from a marine-derived Aspergillus sydowii strain CUGB-F126. Their structures were elucidated by spectroscopic analysis, including high-resolution mass spectroscopy, and 1D and 2D NMR techniques. All of these compounds did not show inhibitory activity against Staphylococcus aureus and Candida albicans.