Vitamin D may be key for pregnant women with polycystic ovary syndrome

(University of Pennsylvania School of Medicine) Vitamin D may play a key role in helping some women seeking treatment for polycystic ovary syndrome (PCOS)-related infertility get pregnant. PCOS is a hormonal disorder affecting 5 to 10 percent of women of reproductive age. Results of the study show women who were Vitamin D deficient when starting fertility treatments were 40 percent less likely to achieve a pregnancy.
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Publication date: Available online 22 October 2018Source: Sensors and Actuators B: ChemicalAuthor(s): Xiaoyun Wei, Bo Cai, Keke Chen, Lin Cheng, Yezi Zhu, Zixiang Wang, Yue Sun, Wei Liu, Shi-shang Guo, Yuanzhen Zhang, Xing-Zhong ZhaoAbstractFetal nucleated red blood cells (fNRBC) in maternal peripheral blood has the potential for non-invasive prenatal diagnostics (NIPD), given its intrinsic nature carrying total genetic information of the fetus. Unfortunately, the scarcity of fNRBCs in maternal blood circulation greatly hinders the effective isolation of fNRBCs and its further uses for clinical prenatal diagnostics. Herein...
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Doctors prescribe metformin to treat people with type 2 diabetes or polycystic ovary syndrome (PCOS). In rare cases, metformin may cause hair loss. Learn more here.
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Vitamin D deficiency in women diagnosed with polycystic ovary syndrome (PCOS) remarkably decreases the chance of pregnancy, which might be related to its impact on metabolic abnormalities in these patients. It...
Source: Reproductive Biology and Endocrinology - Category: Endocrinology Authors: Tags: Research Source Type: research
CONCLUSION: Overall, the findings of this trial supported that 50,000 IU vitamin D supplementation every other week for 8 weeks had beneficial effects on insulin metabolism, and lipid profile of infertile women with PCOS who are candidate for IVF. These benefits might not be evident upon having sufficient vitamin D levels. TRIAL REGISTRATION: This study was retrospectively registered in the Iranian website ( www.irct.ir ) for clinical trials registration ( http://www.irct.ir : IRCT20170513033941N27). PMID: 30286768 [PubMed - in process]
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Reprod Biol Endocrinol Source Type: research
Abstract Context: The impact of vitamin D deficiency on the success of ovarian stimulation according to underlying infertility diagnosis has not been investigated. Objective: To evaluate the relationship between vitamin D deficiency and reproductive outcomes after ovarian stimulation in women with either polycystic ovary syndrome (PCOS) or unexplained infertility. Design: Retrospective cohort study. Setting: Analysis of randomized controlled trial (RCT) data. Participants: Participants from the Pregnancy in PCOS II RCT (n=607); participants from the Assessment of Multiple Intrauterine Gestation...
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
The impact of vitamin D deficiency on the success of ovulation induction (OI) cycles and the risk pregnancy complications after OI has not been extensively investigated. The goal of this study was to evaluate the relationship between preconception vitamin D status and reproductive outcomes in women with a diagnosis of either PCOS or unexplained infertility treated with OI.
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Conclusions: These results suggest that there is a seasonal driver for PE, with effects that are not modified by parity, latitude, fetal sex, or smoking. https://doi.org/10.1289/EHP963 Received: 14 August 2016 Revised: 24 January 2017 Accepted: 25 January 2017 Published: 29 June 2017 Address correspondence to C.R. Weinberg, Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 USA. Telephone: (919) 541-4927. Email: weinber2@niehs.nih.gov Supplemental Material is available online (https://doi.org/10.1289/EHP963). The authors declare they h...
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