Study of bone metabolism and angiogenesis in patients undergoing High Dose Chemotherapy/autologous Hematopoietic Stem Cell Transplantation

ConclusionsBone resorption declined during HSCT [decrease of TRACP‐5b (p<0.001) and CTX (p=0.006)]. Bone formation declined as well [decrease of bALP and OC (p<0.001 for both)]. RANKL/OPG ratio, an indicator of osteoclastic activation, did not change significantly (p=0.5). Ang1/Ang2 ratio, a vessel equilibrium marker, decreased significantly (p<0.001) suggesting endothelial destabilization. The changes observed in the control group were similar except of bALP and RANKL/OPG ratio. Moreover, Ang1/Ang2 ratio on the day after HSC infusion strongly correlated with time to neutrophil and platelet engraftment (p<0.001 for both). Conclusively, bone turnover and vessel destabilization represent important events during HSCT probably reflecting the effect of chemotherapy.This article is protected by copyright. All rights reserved.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2Fejh.12990

Source: European Journal of Haematology - November 1, 2017 Category: Hematology Authors: Georgios Boutsikas, Evangelos Terpos, Athanasios Papatheodorou, Pantelis Tsirkinidis, Panayiotis Tsirigotis, Anastasia Meletiou, Eleni Lalou, Vasileios Telonis, Anna Zannou, Alexander Kanellopoulos, Zacharoula Galani, Angeliki Stefanou, Panayiotis Tsaftar Tags: Original Article Source Type: research