Different effects of silica added internal or external on in vitro dissolution of indomethacin hot-melt extrudates

Publication date: 20 December 2017 Source:International Journal of Pharmaceutics, Volume 534, Issues 1–2 Author(s): Yulong Xia, Meng Yuan, Yueyang Deng, Xue Ke, Tianyuan Ci The purpose of this work was to investigate the effect on the dissolution behavior when silica was added in different ways. The solid dispersion was prepared by hot-melt extrusion (HME) using indomethacin (IND) as a model drug and Kollidon VA64 as a carrier. In order to change the dissolution behavior, the silica was added during or after the HME respectively, to obtain the corresponding silica internal-added solid dispersion (InSD) and silica external-added solid dispersion (ExSD). According to the results, the internal-added silicon dioxide could reduce the dissolution rate from 66.91%/h to 24.12%/h and the water infiltration rate from 0.37mm/h to 0.16mm/h in the phosphate buffer solution (PBS) of pH 6.8, so the formulation of InSD had a significant sustained release effect. But the infiltration rate of the ExSD was increased to 13.22mm/h when silica was added external, and the density of VA64 in the powder was decreased from 541.87mg/cm3 to 141.87mg/cm3, leading to a weak resistance to the external force, and the powder was easy to be dispersed after wetted by water so that the formulation of ExSD had a relatively higher dissolution rate. This phenomenon was more visible when the phosphate buffer solution was changed to pH 5.6 in which the API was more difficult to be dissolved. Accordingly, diff...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research

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This study compared the effects of different dietary energy contents (11.3, 12.0 and 12.7 MJ ME/ kg feed) fed ad libitum in a feedlot on the carcass quality characteristics (carcass yield, commercial yield, 3-rib cut) of goats introduced to feedlot at 22.2 ± 3.5 kg (18 weeks of age), and slaughtered at five week intervals. The energy content of the finisher diets had no effect (P > 0.05) on any of the traits measured. However, the time spent in the feedlot influenced (P 
Source: Small Ruminant Research - Category: Zoology Source Type: research
Publication date: Available online 18 March 2019Source: Ticks and Tick-borne DiseasesAuthor(s): Alessandra Ésther de Mendonça, Raiana Gonçalves Moreira, Maria da Penha Henriques do Amaral, Caio Márcio de Oliveira Monteiro, Valéria de Mello, Fernanda Maria Pinto Vilela, Fernanda Cristina Mendonça Homem, John Furlong, Cláudia Dolinski, Márcia Cristina de Azevedo Prata, Evelize Folly das ChagasAbstractThis work aimed to investigate candidate biological control agents against the cattle tick Rhipicephalus microplus by studying three entomopathogenic nematodes (EPN) isolat...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Conclusions: B cells and NK cells closely correlate with patients' condition and may help to diagnose AP more accurately and reflect treatment effect of AP in time, affecting the recovery speed of patients with M-AP, which may help physicians to better understand the pathophysiology of pancreatitis. PMID: 30881449 [PubMed]
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
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Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
In this study, MHC-1 and PDL-1 score in primary and metastatic tumor cells was evaluated in 43 gastric cancer patients with lymph node metastasis. According to our results, the primary tumor PDL-1 score was correlated with the number of metastatic lymph nodes (r = 0.258; p = 0.024) and primary tumor size (r = 0.341; p = 0.045). A similar correlation was found between the primary tumor PDL-1 score and the metastatic tumor PDL-1 score (r = 0.213; p = 0.015). In our study, MHC-1 was found to be higher in primary tumors than metastatic tumors, although not statistically significant (p = 0.054). The results of our study showed ...
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
Conclusion: EA and MB were able to regulate the concentration of CRH in serum and protein expression in the peripheral and central at different levels and promote the recovery of the HPA axis that may be the basis for EA and MB to improve colonic pathology and alleviate anxiety behavior in DSS-induced colitis. PMID: 30881446 [PubMed]
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
Authors: McCarthy AJ, O'Reilly SM, Shanley J, Geraghty R, Ryan EJ, Cullen G, Sheahan K Abstract Background: As the malignant potential of sessile serrated lesions/polyps (SSL/Ps) and traditional serrated adenomas (TSAs) has been clearly demonstrated, it is important that serrated polyps are identified and correctly classified histologically. Aim: Our aim was to characterize the clinicopathological features of a series of SSL/Ps &TSAs, to assess the accuracy of the pathological diagnosis, the incidence, and the rate of dysplasia in SSL/Ps &TSAs. Methods: We identified all colorectal serrated polyps b...
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
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Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
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Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research
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Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research
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