Integrin-linked kinase: A new actor in the ageing process?

Integrin-linked kinase: A new actor in the ageing process?
Exp Gerontol. 2017 Oct 31;:
Authors: Olmos G, López-Ongil S, Ruiz Torres MP
Abstract
Integrin-linked kinase (ILK) is a protein located in focal adhesion complexes that is linked to the cytoplasmic domain of integrin receptors. Together with PINCH and parvin, ILK forms the IPP complex, which is associated with conserved intracellular signalling pathways and integrin regulation of the actin cytoskeleton. ILK plays an essential role in a wide variety of cellular functions, including cell migration, differentiation, survival, and division. The present review summarizes recent evidence, suggesting a new role for ILK in organismal ageing and cellular senescence, indicating that ILK is a key regulator of longevity and premature cellular senescence induced by extracellular stressors.
PMID: 29101014 [PubMed - as supplied by publisher]

Source: Experimental Gerontology - October 31, 2017 Category: Geriatrics Authors: Olmos G, López-Ongil S, Ruiz Torres MP Tags: Exp Gerontol Source Type: research