Relationship between fibrillin-1 genotype and severity of cardiovascular involvement in Marfan syndrome
Conclusions
Patients with an HI mutation had a more severely affected aortic phenotype, with larger aortic root diameters and a more rapid dilation rate, and tended to have an increased risk of death and dissections compared with patients with a DN mutation.
Source: Heart - Category: Cardiology Authors: Franken, R., Teixido-Tura, G., Brion, M., Forteza, A., Rodriguez-Palomares, J., Gutierrez, L., Garcia Dorado, D., Pals, G., Mulder, B. J., Evangelista, A. Tags: Editor's choice Aortic and vascular disease Source Type: research