Epigenetic Regulation of ZBTB18 Promotes Glioblastoma Progression

This study characterizes the role of the putative tumor suppressor ZBTB18 and its regulation by promoter hypermethylation, which appears to be a common mechanism to silence ZBTB18 in the mesenchymal subtype of GBM and provides a new mechanistic opportunity to specifically target this tumor subclass. Mol Cancer Res; 15(8); 998–1011. ©2017 AACR.

Source: Molecular Cancer Research - August 1, 2017 Category: Cancer & Oncology Authors: Fedele, V., Dai, F., Masilamani, A. P., Heiland, D. H., Kling, E., Gätjens-Sanchez, A. M., Ferrarese, R., Platania, L., Soroush, D., Kim, H., Nelander, S., Weyerbrock, A., Prinz, M., Califano, A., Iavarone, A., Bredel, M., Carro, M. S. Tags: Chromatin, Epigenetics, and RNA Regulation Source Type: research