KITD816V Induces SRC-Mediated Tyrosine Phosphorylation of MITF and Altered Transcription Program in Melanoma

This study demonstrates that an oncogenic tyrosine kinase mutant, KITD816V, can alter the transcriptional program of the transcription factor MITF in melanoma Mol Cancer Res; 15(9); 1265–74. ©2017 AACR.

Source: Molecular Cancer Research - August 31, 2017 Category: Cancer & Oncology Authors: Phung, B., Kazi, J. U., Lundby, A., Bergsteinsdottir, K., Sun, J., Goding, C. R., Jönsson, G., Olsen, J. V., Steingrimsson, E., Rönnstrand, L. Tags: Oncogenes and Tumor Suppressors Source Type: research