The Landscape of Isoform Switches in Human Cancers

This study indicates that isoform switches with predicted functional consequences are common and important in dysfunctional cells, which in turn means that gene expression should be analyzed at the isoform level. Mol Cancer Res; 15(9); 1206–20. ©2017 AACR.
Source: Molecular Cancer Research - Category: Cancer & Oncology Authors: Tags: Genomics Source Type: research

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Thank you, for providing me with the opportunity  to respond to Dr Grant’s Letter to the Editor regarding: Preserving Pulmonary Function: A Palliative Approach published in the September 2019 issue of The Journal for Nurse Practitioner. Dr. Grant is on-target and not only following recommendations for earlier palliative interventions for cancer patients by the American Society of Oncologists (ASCO) and the National Comprehensive Cancer Network (NCCN). Equally important to recognize is the National Quality Forum (NQF) who serve as the gold standard for patient outcome measurements in the U.S.
Source: The Journal for Nurse Practitioners - Category: Nursing Authors: Tags: Letter to the Editor Source Type: research
Authors: Koyama N, Aoshiba K, Nakamura H Abstract The aim of this study was to assess the association of serum C-reactive protein (CRP) levels with outcomes in 81 patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). Patients with high serum CRP levels had lower therapeutic responses to EGFR-tyrosine kinase inhibitors (43.8%), and shorter time to treatment failure (TTF; 5.8 months) and overall survival (OS; 14.2 months) than those with low CRP levels. In multivariate analysis, serum CRP level was associated with TTF (hazard ratio [HR] 4.86) and OS (HR 49.42). High serum C...
Source: Cancer Investigation - Category: Cancer & Oncology Tags: Cancer Invest Source Type: research
Authors: Sher AF, Golshani GM, Wu S Abstract Background: Pembrolizumab as an immune checkpoint inhibitor (ICI) has emerged as an effective treatment for many cancers. It has unique immune related adverse events and little is known about its risk of fatal adverse events (FAE). We conducted a meta-analysis of clinical trials to determine the incidence and risk of fatal adverse events with pembrolizumab.Methods: A systematic search for phase I-III clinical trials of pembrolizumab was conducted using databases including PUBMED, and abstracts presented at the American Society of Clinical Oncology (ASCO) conferences unti...
Source: Cancer Investigation - Category: Cancer & Oncology Tags: Cancer Invest Source Type: research
Publication date: Available online 27 January 2020Source: Mutation Research/Fundamental and Molecular Mechanisms of MutagenesisAuthor(s): Samuel Buxton, Yvonne Voges, Claudia Donath, Adriana OllerAbstractNickel metal is a naturally occurring element used in many industrial and consumer applications. Human epidemiological data and animal cancer bioassays indicate that nickel metal is not likely to be a human carcinogen. Yet, nickel metal is classified as a suspected human carcinogen (CLP) and possibly carcinogenic to humans (IARC). There are no reliable studies on the potential for nickel metal to induce gene and micronucle...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - Category: Cytology Source Type: research
A new study from New York University Grossman School of Medicine has found that cancer patients who took one dose of psilocybin had more positive feelings and less death anxiety.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
(University of South Florida (USF Health)) A study led by researchers at the University of South Florida Morsani College of Medicine discovered that three major proinflammatory mediators -- interlukin-1 beta, tumor necrosis factor alpha, and thrombin -- individually and especially when combined, directly drive capillary loss known to occur in diseases such as hypertension, diabetes, cardiovascular diseases, neurodegenerative diseases and malignant cancer. Using an innnovative 3-D cell model, the investigators also identified combinations of existing drugs that can block the regression of these tiny blood vessels.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Sensitive and selective SERS probe for detecting the activity of γ-glutamyl transpeptidase in serum. Anal Chim Acta. 2020 Feb 22;1099:119-125 Authors: Jiang L, Guo D, Wang L, Chang S, Li JB, Zhan DS, Fodjo EK, Gu HX, Li DW Abstract γ-Glutamyl transpeptidase (GGT) has attracted considerable attention for its regulatory effect on glutathione metabolism in living organisms; further, its close relationship with physiological dysfunctions such as hepatitis and liver cancers has enhanced its applicability. Therefore, the accurate detection of GGT levels is particularly important for the early di...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
Authors: Wang C, Yin W, Chen P PMID: 31985182 [PubMed - as supplied by publisher]
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
Source: Vascular Health and Risk Management - Category: Cardiology Tags: Breast Cancer: Targets and Therapy Source Type: research
This study was designed to assess non-target organ doses from Co-60 teletherapy for patients with nasopharyngeal cancer and to estimate the risk of radiation-induced secondary cancer. Specific organ-absorbed doses were evaluated in anatomically realistic 15-year-old and adult male phantoms based on Monte Carlo simulation. The assessed organ doses were used to calculate the lifetime secondary cancer risks in non-target organs according to the BEIR VII risk models. Survival information and the baseline cancer risks were associated with statistical data for the Tanzanian population. The average absorbed doses in non-target or...
Source: Radiation Physics and Chemistry - Category: Physics Source Type: research
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