Inhibition of Ciliogenesis Promotes Hedgehog Signaling, Tumorigenesis, and Metastasis in Breast Cancer

This study identifies inhibition of ciliogenesis as an important event for activation of Hedgehog signaling and progression of breast cancer to a more aggressive, metastatic disease.
Implications: These findings change the way we understand how cancer cells turn on a critical signaling pathways and a provide rationale for developing novel therapeutic approaches to target noncanonical Hedgehog signaling for the treatment of breast cancer. Mol Cancer Res; 15(10); 1421–30. ©2017 AACR.

Source: Molecular Cancer Research - October 1, 2017 Category: Cancer & Oncology Authors: Hassounah, N. B., Nunez, M., Fordyce, C., Roe, D., Nagle, R., Bunch, T., McDermott, K. M. Tags: Signal Transduction Source Type: research