Developing the WCRF International/University of Bristol Methodology for Identifying and Carrying Out Systematic Reviews of Mechanisms of Exposure-Cancer Associations

Conclusions: We have developed novel tools for identifying mechanisms and carrying out systematic reviews of mechanistic studies of exposure–disease relationships. In doing so, we have outlined how we have overcome the challenges that we faced and provided researchers with practical guides for conducting mechanistic systematic reviews.
Impact: The aforementioned methodology and tools will allow potential mechanisms to be identified and the strength of the evidence underlying a particular mechanism to be assessed. Cancer Epidemiol Biomarkers Prev; 26(11); 1667–75. ©2017 AACR.

Source: Cancer Epidemiology Biomarkers and Prevention - October 31, 2017 Category: Cancer & Oncology Authors: Lewis, S. J., Gardner, M., Higgins, J., Holly, J. M. P., Gaunt, T. R., Perks, C. M., Turner, S. D., Rinaldi, S., Thomas, S., Harrison, S., Lennon, R. J., Tan, V., Borwick, C., Emmett, P., Jeffreys, M., Northstone, K., Mitrou, G., Wiseman, M., Thompson, R. Tags: Research Articles Source Type: research