SUMOylation controls stem cell proliferation and regional cell death through Hedgehog signaling in planarians.
We present evidence indicating that Ubc9-induced regional cell death is preceded by alterations in transcription and spatial expression of repressors and activators of the Hedgehog signaling pathway. Our results demonstrate that SUMOylation acts as a regional-specific cue to regulate cell fate during tissue renewal and regeneration.
PMID: 29098326 [PubMed - as supplied by publisher]
Source: Cellular and Molecular Life Sciences : CMLS - Category: Cytology Authors: Thiruvalluvan M, Barghouth PG, Tsur A, Broday L, Oviedo NJ Tags: Cell Mol Life Sci Source Type: research