Model-based optimization of G-CSF treatment during cytotoxic chemotherapy

ConclusionsWe conclude that we established a model of human granulopoiesis under chemotherapy which allows predictions of yet untested G-CSF schedules, comparisons between them, and optimization of filgrastim and pegfilgrastim treatment. As a general rule of thumb, G-CSF treatment should not be started too early and patients could profit from filgrastim treatment continued until the end of the chemotherapy cycle.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research