Redox Regulation of Circadian Molecular Clock in Chronic Airway Diseases.

Redox Regulation of Circadian Molecular Clock in Chronic Airway Diseases. Free Radic Biol Med. 2017 Oct 30;: Authors: Sundar IK, Sellix MT, Rahman I Abstract At the cellular level, circadian timing is maintained by the molecular clock, a family of interacting clock gene transcription factors, nuclear receptors and kinases called clock genes. Daily rhythms in pulmonary function are dictated by the circadian timing system, including rhythmic susceptibility to the harmful effects of air born pollutants, exacerbations in patients with chronic airway disease and the immune-inflammatory response to infection. Further, evidence strongly suggests that the circadian molecular clock has a robust reciprocal interaction with redox signaling and plays a considerable role in the response to oxidative/carbonyl stress. Disruption of the circadian timing system, particularly in airway cells, impairs pulmonary rhythms and lung function, enhances oxidative stress due to airway inhaled pollutants like cigarette smoke and airborne particulate matter and leads to enhanced inflammosenescence, inflammasome activation, DNA damage and fibrosis. Herein, we briefly review recent evidence supporting the role of the lung clock and redox signaling in the lungs, the role of redox signaling in inflammation, oxidative stress and DNA damage responses in lung diseases and their exacerbations. We further describe the potential for clock genes as novel biomarkers and the...
Source: Free Radical Biology and Medicine - Category: Biology Authors: Tags: Free Radic Biol Med Source Type: research