Antidepressant Mechanism Research of Acupuncture: Insights from a Genome-Wide Transcriptome Analysis of Frontal Cortex in Rats with Chronic Restraint Stress.

In this study, we randomly divided the rats into control group (C), model group (M), fluoxetine group (F), and acupuncture group (A), used open-field test to ascertain whether acupuncture affects chronic restraint stress (CRS) induced depression-like behaviors of rats, and explored the antidepressant mechanism of acupuncture at the molecular level of transcriptome in the frontal cortex of CRS rats by RNA-sequencing (RNA-seq). According to differentially expressed genes (DEG) analysis, we identified 134, 46, and 89 response genes differentially expressed in C versus M, F versus M, and A versus M, respectively. Through Gene Ontology (GO) term enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, we identified the gene sets involved in extracellular space, inflammatory response, Toll-like receptor signaling pathway, chemokine signaling pathway, and TNF signaling pathway. In this study, RNA-seq technology was used to investigate the frontal cortex genome-wide transcriptomes in depression rats under CRS, which suggested that the antidepressant effect of acupuncture is effective and has a multitarget characteristic, which may be related to amino acid metabolism and inflammatory pathways, especially the Toll-like receptor signaling pathway, TNF signaling pathway, and NF-kappa B signaling pathway. PMID: 29098013 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Related Links:

In this study, we conducted a cross-sectional survey among 419 acupuncturists nation-wide to investigate the top 10 and top 99 acupuncture indications in private clinics in the United States. We found the top 10 indications to be: lower back pain, depression, anxiety, headache, arthritis, allergies, general pain, female infertility, insomnia, neck pain and frozen shoulder. Among the top 99 indications, pain represents the largest category; and mental health management, especially for mood disorders, is in greatest demand. The following popular groups are: immune system dysfunctions, gastrointestinal diseases, gynecology an...
Source: The American Journal of Chinese Medicine - Category: Complementary Medicine Authors: Tags: Am J Chin Med Source Type: research
What is holistic therapy? Holistic therapy is defined as non-medicinal recovery methods. At Cliffside, we use holistic therapy to complement traditional treatment practices. Holistic therapy aims to bring the mind, body and spirit into alignment. It focuses on the patient’s overall well-being while also treating physical symptoms of addiction and withdrawal. They can be very beneficial to addiction therapy because they can be calming, healing outlets to use in place of old behaviors. They support the constant growth of each patient – mentally, physically, emotionally and spiritually. Holistic therapy aids in he...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Acupuncture Addiction Addiction Recovery Alcohol Alcohol Rehab Information Alcoholism Complementary Therapies Drinking Drug Rehab Information Drug Treatment Eating Disorders Exercise Healthy Eating and Recovery Holistic Treatment Source Type: blogs
Publication date: Available online 22 April 2018Source: EXPLOREAuthor(s): Eran Ben-Arye, Ilana Doweck, Elad Schiff, Noah SamuelsAbstractContextChemotherapy-induced taste disorder (CITD) is a common adverse effect among patients with cancer, with no effective known treatment.ObjectivesExploring the impact of a patient-tailored complementary and integrative medicine (CIM) treatment program on CITD-related severity.DesignProspective study on patients’ chart.SettingIntegrative oncology program operating within the Clalit Healthcare Oncology Service in northern Israel.PatientsPatients were referred by their oncology healt...
Source: EXPLORE: The Journal of Science and Healing - Category: Complementary Medicine Source Type: research
ConclusionsFew clinical trials of acupuncture, and complementary medicine interventions generally, document details of the process by which they ensured the model validity of their trial intervention. It is recommended that researchers in acupuncture, and other forms of complementary medicine, adopt appropriate methodological approaches to ensure model validity.
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
This study characterizes and evaluates how Integrative Healing Services (IHS) affects patient pain levels and length of stay. We also performed a literature review to examine national trends in inpatient integrative healing.MethodsAn IHS team (e.g. acupuncture, healing touch, music therapy, pet therapy, and counseling) was incorporated into the treatment regimen of neurosurgery inpatients (with>4 days of stay) with chronic or intractable pain, stress or depression, and/or patients intolerant to or who failed physical or occupational therapy.Results34 charts were retrospectively reviewed, with 17 patients receiving IHS...
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
(Natural News) A study published in BMC Complementary and Alternative Medicine examined the therapeutic effects of acupuncture on behavioral changes caused by lipopolysaccharides (LPS), proving the far-reaching benefits of this ancient treatment approach. Thanks to the machinations of the media, you probably see emotional disorders like depression and anxiety as mere outcomes of a troubled...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Publication date: Available online 22 April 2018Source: EXPLOREAuthor(s): Eran Ben-Arye, Ilana Doweck, Elad Schiff, Noah SamuelsAbstractContextChemotherapy-induced taste disorder (CITD) is a common adverse effect among patients with cancer, with no effective known treatment.ObjectivesExploring the impact of a patient-tailored complementary and integrative medicine (CIM) treatment program on CITD-related severity.DesignProspective study on patients’ chart.SettingIntegrative oncology program operating within the Clalit Healthcare Oncology Service in northern Israel.PatientsPatients were referred by their oncology healt...
Source: EXPLORE: The Journal of Science and Healing - Category: Complementary Medicine Source Type: research
ConclusionsFew clinical trials of acupuncture, and complementary medicine interventions generally, document details of the process by which they ensured the model validity of their trial intervention. It is recommended that researchers in acupuncture, and other forms of complementary medicine, adopt appropriate methodological approaches to ensure model validity.
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
This study characterizes and evaluates how Integrative Healing Services (IHS) affects patient pain levels and length of stay. We also performed a literature review to examine national trends in inpatient integrative healing.MethodsAn IHS team (e.g. acupuncture, healing touch, music therapy, pet therapy, and counseling) was incorporated into the treatment regimen of neurosurgery inpatients (with>4 days of stay) with chronic or intractable pain, stress or depression, and/or patients intolerant to or who failed physical or occupational therapy.Results34 charts were retrospectively reviewed, with 17 patients receiving IHS...
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
Conclusions Few clinical trials of acupuncture, and complementary medicine interventions generally, document details of the process by which they ensured the model validity of their trial intervention. It is recommended that researchers in acupuncture, and other forms of complementary medicine, adopt appropriate methodological approaches to ensure model validity.
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
More News: Acupuncture | Alternative and Complementary Therapies | Complementary Medicine | Depression | Fluoxetine | Genetics | Men | Prozac | Study