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Antidepressant Mechanism Research of Acupuncture: Insights from a Genome-Wide Transcriptome Analysis of Frontal Cortex in Rats with Chronic Restraint Stress.

In this study, we randomly divided the rats into control group (C), model group (M), fluoxetine group (F), and acupuncture group (A), used open-field test to ascertain whether acupuncture affects chronic restraint stress (CRS) induced depression-like behaviors of rats, and explored the antidepressant mechanism of acupuncture at the molecular level of transcriptome in the frontal cortex of CRS rats by RNA-sequencing (RNA-seq). According to differentially expressed genes (DEG) analysis, we identified 134, 46, and 89 response genes differentially expressed in C versus M, F versus M, and A versus M, respectively. Through Gene Ontology (GO) term enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, we identified the gene sets involved in extracellular space, inflammatory response, Toll-like receptor signaling pathway, chemokine signaling pathway, and TNF signaling pathway. In this study, RNA-seq technology was used to investigate the frontal cortex genome-wide transcriptomes in depression rats under CRS, which suggested that the antidepressant effect of acupuncture is effective and has a multitarget characteristic, which may be related to amino acid metabolism and inflammatory pathways, especially the Toll-like receptor signaling pathway, TNF signaling pathway, and NF-kappa B signaling pathway. PMID: 29098013 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

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Aanchal Satija, Sushma BhatnagarIndian Journal of Palliative Care 2017 23(4):468-479Cancer patients are often poly-symptomatic which distressingly affects their quality of lives (QOLs). Alhough, conventional management provides adequate symptom control, yet is coupled with some limitations. Complementary therapies (CTs) have shown beneficial effects in cancer patients for symptomatic relief. The aim of this article is to provide evidence-based review of commonly used CTs for symptom management in cancer care. Hypnosis has promising evidence to be used for managing symptoms such as pain, chemotherapy-induced nausea/vomiting...
Source: Indian Journal of Palliative Care - Category: Palliative Care Authors: Source Type: research
Follow me on Twitter @drClaire More and more, I have families in my practice who are trying out treatments and therapies I didn’t prescribe. Most of the time, it’s absolutely fine. Other times, it’s not. “Complementary and alternative medicine” is a broad term that refers to treatments that are not generally part of traditional Western medicine. It includes things like herbal remedies, dietary supplements or alternative diets, acupuncture, acupressure, homeopathy, Chinese remedies, Reiki, or hypnosis. It also includes things like yoga or meditation — and chiropractic medicine. Many of th...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Children's Health Complementary and alternative medicine Parenting Source Type: blogs
This article presents current evidence-based recommendations for complementary therapies in the treatment of depression, anxiety, and posttraumatic stress disorder. PMID: 28802467 [PubMed - in process]
Source: The Medical Clinics of North America - Category: General Medicine Authors: Tags: Med Clin North Am Source Type: research
Publication date: 2017 Source:International Review of Neurobiology, Volume 134 Author(s): Indu Subramanian The use of complementary and alternative medicine (CAM) therapy in nonmotor symptoms (NMS) for Parkinson disease (PD) is growing worldwide. Well-performed, systematic evidence-based research is largely lacking in this area and many studies include various forms of CAM with small patient numbers and a lack of standardization of the approaches studied. Taichi, Qigong, dance, yoga, mindfulness, acupuncture, and other CAM therapies are reviewed and there is some evidence for the following: Taichi in sleep and PDQ39; danc...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
Publication date: Available online 14 July 2017 Source:International Review of Neurobiology Author(s): Indu Subramanian The use of complementary and alternative medicine (CAM) therapy in nonmotor symptoms (NMS) for Parkinson disease (PD) is growing worldwide. Well-performed, systematic evidence-based research is largely lacking in this area and many studies include various forms of CAM with small patient numbers and a lack of standardization of the approaches studied. Taichi, Qigong, dance, yoga, mindfulness, acupuncture, and other CAM therapies are reviewed and there is some evidence for the following: Taichi in sleep an...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
Approximately 18% of the US adult population has a mental illness, yet only 13% with mental illness receive any treatment. Although pharmacotherapy and psychotherapy are the mainstays of treatment, treatment discontinuation and failure are common. Skepticism toward such treatments have fueled interest and use of complementary therapies, such as acupuncture, meditation, and natural products. Many medical providers are unaware of the use of these therapies by their patients, and knowledge of the evidence base for these therapies is often lacking. This review presents current evidence-based recommendations for complementary t...
Source: Medical Clinics of North America - Category: Primary Care Authors: Source Type: research
Publication date: Available online 1 June 2017 Source:Journal of Acupuncture and Meridian Studies Author(s): Sybille Kramer, Dominik Irnich, Stefan Lorenzl The use of complementary and alternative medicine methods such as acupuncture in palliative care has increased over the past years. Well-planned trials are warranted to show its effectiveness in relieving distressing symptoms. The development of treatment schemes to be used in the trial for both acupuncture and medical symptom control is challenging, as both acupuncture and palliative care are highly individualized. Thus, standardized care plans of a randomized control...
Source: Journal of Acupuncture and Meridian Studies - Category: Complementary Medicine Source Type: research
Publication date: Available online 1 June 2017 Source:Journal of Acupuncture and Meridian Studies Author(s): Sybille Kramer, Dominik Irnich, Stefan Lorenzl The use of complementary and alternative medicine (CAM) methods as acupuncture in palliative care has increased over the last years. Well-planned trials are needed to show its effectiveness in relieving distressing symptoms. The development of treatment schemes to be used in the trial for both acupuncture and medical symptom control is challenging: Both acupuncture and palliative care are highly individualized. Thus standardized care plans of a randomized controlled tr...
Source: Journal of Acupuncture and Meridian Studies - Category: Complementary Medicine Source Type: research
Conclusions. Acupuncture provided more effective poststroke pain relief than sham acupuncture treatment. However, acupuncture had no better effect on neurological, functional, and psychological improvement. PMID: 28408941 [PubMed - in process]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Conclusion. This systematic review indicates that acupuncture could be an alternative therapy to medication for treating depression-related insomnia. PMID: 28286776 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
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